Redox deracemization of α-substituted 1,3-dihydroisobenzofurans  

作　　者：Xiaohan Chen Ran Zhao Ziqiang Liu Shutao Sun Yingang Ma Qingyun Liu Xia Sun Lei Liu 

机构地区：[1]School of Pharmaceutical Sciences,Cheeloo College of Medicine,Shandong University,Ji'nan 250012,China [2]College of Chemical and Biological Engineering,State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology,Shandong University of Science and Technology,Qingdao 266590,China [3]School of Chemistry and Chemical Engineering,Shandong University,Ji'nan 250100,China [4]Shenzhen Research Institute of Shandong University,Shenzhen 518057,China [5]Department of Pharmacology,School of Basic Medical Sciences,Cheeloo College of Medicine,Shandong University,Ji'nan 250012,China

出　　处：《Chinese Chemical Letters》2021年第7期2305-2308,共4页中国化学快报（英文版）

基　　金：financial supported by the National Natural Science Foundation of China(Nos.21971148);Shenzhen Special Funds(No.JCYJ20190807093805572)。

摘　　要：Chiralα-substituted 1,3-dihydroisobenzofurans are key scaffolds in a number of bioactive natural products and synthetic pharmaceuticals.However,catalytic asymmetric approaches have been rarely developed.Here,a redox deracemization technology is adopted to address the catalytic asymmetric synthesis.A broad range ofα-aryl substituted 1,3-dihydroisobenzofurans are effectively deracemized in high efficiency with excellent ee.α-Alkynyl substituted ethers were also compatible with the deracemization technology.

关 键 词：1 3-Dihydroisobenzofuran Asymmetric catalysis Redox deracemization Oxocarbenium ion Synthetic method 

分 类 号：O626.11[理学—有机化学]