Cascade reaction to 1H-pyrazoles from hydrazones via sodium Ni-trite promoted dual C-C/C-N formation,annulation and aromatization with 1,2-dichloroethane  

作　　者：Liqiang Hao Hongyan Liu Zheng Zhang Fuqiang Wen Chengcai Xia Zengfen Pang 

机构地区：[1]Institute of Pharmacology,Pharmacy College,Shandong First Medical University&Shandong Academy of Medical Sciences,Tai'an 271016,China [2]Shandong Cancer Hospital and Institute,Shandong First Medical University&Shandong Academy of Medical Sciences,Ji'nan 250117,China

出　　处：《Chinese Chemical Letters》2021年第7期2309-2312,共4页中国化学快报（英文版）

基　　金：financial support for this research from Shandong Provincial Natural Science Foundation(No.ZR2017LB006);Academic promotion programme of Shandong First Medical University(No.2019LJ003)。

摘　　要：A novel route for tandem C-C/C-N formation,annulation and aromatization of hydrazones with 1,2-dichloroethane to synthesize 1 H-pyrazoles has been developed.Furthermore,the 1,2-dichloroethane serves as alkylation reagent in good to excellent yields.This methodology features mild reaction conditions and good functional group tolerance,providing a direct approach for the preparation of 1 Hpvrazoles.

关 键 词：Tandem HYDRAZONES 1 2-DICHLOROETHANE 1H-Pyrazoles ANNULATION 

分 类 号：O621.25[理学—有机化学]