The occurrence order and cross-talk of different tRNA modifications  

作　　者：Jing Li Wen-Yu Zhu Wen-Qing Yang Cai-Tao Li Ru-Juan Liu 

机构地区：[1]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《Science China(Life Sciences)》2021年第9期1423-1436,共14页中国科学（生命科学英文版）

基　　金：supported by the National Key Research and Development Program of China(2020YFA0803400);the National Natural Science Foundation of China(32022040,31971230,31770842);the China Postdoctoral Science Foundation Grants(2020M671253)。

摘　　要：Chemical modifications expand the composition of RNA molecules from four standard nucleosides to over 160 modified nucleosides,which greatly increase the complexity and utility of RNAs.Transfer RNAs(tRNAs)are the most heavily modified cellular RNA molecules and contain the largest variety of modifications.Modification of tRNAs is pivotal for protein synthesis and also precisely regulates the noncanonical functions of tRNAs.Defects in tRNA modifications lead to numerous human diseases.Up to now,more than 100 types of modifications have been found in tRNAs.Intriguingly,some modifications occur widely on all tRNAs,while others only occur on a subgroup of tRNAs or even only a specific tRNA.The modification frequency of each tRNA is approximately 7% to 25%,with 5-20 modification sites present on each tRNA.The occurrence and modulation of tRNA modifications are specifically noticeable as plenty of interplays among different sites and modifications have been discovered.In particular,tRNA modifications are responsive to environmental changes,indicating their dynamic and highly organized nature.In this review,we summarized the known occurrence order,cross-talk,and cooperativity of tRNA modifications.

关 键 词：TRNA RNA modification RNA methylation occurrence order CROSS-TALK 

分 类 号：Q522[生物学—生物化学]