Interactions between commensal bacteria and viral infection:insights for viral disease control in farmed animals  

作　　者：Chao Ran Yu Li Xufa Ma Yadong Xie Mingxu Xie Yuting Zhang Wei Zhou Yalin Yang Zhen Zhang Li Zhou Kaijian Wei Zhigang Zhou 

机构地区：[1]Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs,Feed Research Institute,Chinese Academy of Agricultural Sciences,Beijing 100081,China [2]Sino-Norway Joint Lab on Fish Gut Microbiota,Feed Research Institute,Chinese Academy of Agricultural Sciences,Beijing 100081,China [3]College of Fisheries,Huazhong Agricultural University,Wuhan 430070,China [4]State Key Laboratory of Freshwater Ecology and Biotechnology,Institute of Hydrobiology,The Innovation Academy of Seed Design,Chinese Academy of Sciences,Wuhan 430072,China

出　　处：《Science China(Life Sciences)》2021年第9期1437-1448,共12页中国科学（生命科学英文版）

基　　金：supported by the National Key R&D Program of China(2018YFD0900400);the National Natural Science Foundation of China(31925038,31872584,31972807)。

摘　　要：Viral diseases cause serious economic loss in farmed animals industry.However,the efficacy of remedies for viral infection in farmed animals is limited,and treatment strategies are generally lacking for aquatic animals.Interactions of commensal microbiota and viral infection have been studied in recent years,demonstrating a third player in the interaction between hosts and viruses.Here,we discuss recent developments in the research of interactions between commensal bacteria and viral infection,including both promotion and inhibition effect of commensal bacteria on viral pathogenesis,as well as the impact of viral infection on commensal microbiota.The antiviral effect of commensal bacteria is mostly achieved through priming or regulation of the host immune responses,involving differential microbial components and host signaling pathways,and gives rise to various antiviral probiotics.Moreover,we summarize studies related to the interaction between commensal bacteria and viral infection in farmed animals,including pigs,chickens,fish and invertebrate species.Further studies in this area will deepen our understanding of antiviral immunity of farmed animals in the context of commensal microbiota,and promote the development of novel strategies for treatment of viral diseases in farmed animals.

关 键 词：VIRUS intestinal microbiota commensal bacteria farmed animals PROBIOTICS 

分 类 号：S855.3[农业科学—临床兽医学]