阿奇霉素与左氧氟沙星在慢性支气管炎治疗中的应用及评价  

Application and Evaluation of Azithromycin and Levofloxacin in the Treatment of Chronic Bronchitis

作　　者：周扬 ZHOU Yang(Liaoning Yingkou Economic and Technological Development Zone Central Hospital(Yingkou Sixth People's Hospital),Yingkou 115007,China)

机构地区：[1]辽宁省营口经济技术开发区中心医院(营口市第六人民医院),辽宁营口115007

出　　处：《中国医药指南》2021年第25期15-17,共3页Guide of China Medicine

摘　　要：目的观察并评价对慢性支气管炎患者联合应用阿奇霉素与左氧氟沙星进行治疗的临床效果。方法选取我院收治的102例慢性支气管炎患者为研究对象,入选时间为2017年3月至2019年2月。按照随机数字法将其分为对照组(单纯采用阿奇霉素进行治疗,51例)与观察组(联合应用阿奇霉素与左氧氟沙星治疗,51例)。统计两组患者的症状改善时间、药物治疗有效率以及不良反应发生情况,并进行评价。结果①症状消失时间方面,观察组患者的发热、呼吸困难、肺啰音以及咳痰咳嗽等症状的消失时间均显著低于对照组,P<0.05。②治疗总有效率方面,观察组升高96.08%(49/51),高于对照组的80.39%(41/51),P<0.05。③不良反应方面,观察组患者呕吐、轻度腹泻以及ALT(丙氨酸转氨酶)等不良反应发生率为7.84%(4/51),对照组为7.32%(3/51),两组比较无明显差异(P>0.05)。结论对于慢性支气管炎患者,通过联合应用阿奇霉素与左氧氟沙星进行治疗,可有效改善其发热、呼吸困难、咳嗽等症状,疗效确切,安全性高,可加快患者身体的康复。Objective To observe and evaluate the clinical effect of treating chronic bronchitis with azithromycin and levofloxacin.Methods One hundred and two patients with chronic bronchitis admitted to our hospital were selected as the study objects,and the time of enrollment was from March 2017 to February 2019.According to the random number method,they were divided into the control group(51 cases treated with azithromycin alone)and the observation group(51 cases treated with azithromycin and levofloxacin).The time of symptom improvement,effective rate of drug treatment and occurrence of adverse reactions of patients in the two groups were counted and evaluated.Results(1)In terms of symptom disappearance time,the disappearance time of fever,dyspnea,lung rhonus and cough in the observation group was significantly lower than that in the control group(P<0.05,the difference was statistically significant).(2)In terms of the total effective rate of treatment,the observation group was as high as 96.08%(49/51),compared with the control group,80.39%(41/51)was significantly increased,with statistically significant difference(P<0.05).(3)In terms of adverse reactions,the incidence of adverse reactions such as vomiting,mild diarrhea and elevated ALT(glutamate transaminase)in the observation group was 7.84%(4/51),while that in the control group was 7.32%(3/51).There was no significant difference between the two groups(P>0.05).Conclusion For patients with chronic bronchitis,the combination of azithromycin and levofloxacin for treatment can effectively improve their fever,dyspnea,cough and other symptoms,effective,high safety,can speed up the recovery of patients,worthy of promotion.

关 键 词：慢性支气管炎 阿奇霉素 左氧氟沙星 治疗效果 

分 类 号：R562.21[医药卫生—呼吸系统]