A short review on cell-based biosensing:challenges and breakthroughs in biomedical analysis  

作　　者：Mihaela Gheorghiu 

机构地区：[1]Biosensors Department,International Centre of Biodynamics,Bucharest 060101,Romania.

出　　处：《The Journal of Biomedical Research》2021年第4期255-263,共9页生物医学研究杂志（英文版）

摘　　要：Current cell-based biosensors have progressed substantially from mere alternatives to molecular bioreceptors into enabling tools for interfacing molecular machineries and gene circuits with microelectronics and for developing groundbreaking sensing and theragnostic platforms.The recent literature concerning whole-cell biosensors is reviewed with an emphasis on mammalian cells,and the challenges and breakthroughs brought along in biomedical analyses through novel biosensing concepts and the synthetic biology toolbox.These recent innovations allow development of cell-based biosensing platforms having tailored performances and capable to reach the levels of sensitivity,dynamic range,and stability suitable for high analytic/medical relevance.They also pave the way for the construction of flexible biosensing platforms with utility across biological research and clinical applications.The work is intended to stimulate interest in generation of cell-based biosensors and improve their acceptance and exploitation.

关 键 词：BIOSENSING electro-optical assays synthetic biology cell dynamics cell physiology THERANOSTICS 

分 类 号：R318[医药卫生—生物医学工程] TP212.3[医药卫生—基础医学]