军团菌致病性检测方法研究进展  

Research Progress in Detection Methods of Legionella Pathogenicity

作　　者：王艳晴 任红宇[2] 赵娜[2] 陈海婴[3] 刘明斌 秦天[2] WANG Yan-qing;REN Hong-yu;ZHAO Na;CHEN Hai-ying;LIU Ming-bin;QIN Tian(School of Public Health,Jiangxi Province Key Laboratory of Preventive Medicine,Nanchang University,Nanchang 330006,China;Department of Respiratory,National Institute for Communicable Disease Prevention and Control,Chinese Center for Disease Control and Prevention,State Key Laboratory for Communicable Disease Prevention and Control,Beijing 102206,China;Nanchang Center for Disease Control and Prevention,Nanchang 330038,China)

机构地区：[1]南昌大学公共卫生学院,江西省预防医学重点实验室,南昌330006 [2]中国疾病预防控制中心传染病预防控制所呼吸道传染病室,传染病预防控制所国家重点实验室,北京102206 [3]南昌市疾病预防控制中心,南昌330038

出　　处：《南昌大学学报（医学版）》2021年第4期74-79,共6页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金(81671985);国家科技重大专项(2018ZX10712001007);传染病预防控制国家重点实验室科学基金(2019SKLID403)。

摘　　要：嗜肺军团菌是引起军团菌病的主要病原体,临床表现主要是肺炎样症状和轻症流感样庞蒂亚克热。军团菌病的主要致病机制是军团菌的分泌系统分泌的效应因子和分泌的调控蛋白与宿主细胞间的相互作用。嗜肺军团菌是已知的将近70种军团菌中最普遍存在的,也是临床感染人类最多的菌种。军团菌在自然水环境中广泛存在,但目前针对军团菌致病性检测的方法并不明确。文章主要介绍军团菌致病性检测方法,以期为实际应用选择时提供参考。Legionella pneumophila is the main pathogen causing Legionnaires’disease(LD),which is clinically manifested with pneumonia-like symptoms and mild flu-like Pontiac fever.The main pathogenic mechanism of LD is the interaction between Legionella-secreted effector factors and regulatory proteins and host cells.Legionella pneumophila is the most ubiquitous species of the nearly 70 known species of Legionella,and is also the most common species infecting humans.Legionella is widespread in the natural water environment,but the current methods for detecting Legionella pathogenicity are not clear.This article mainly introduces the methods for detecting the pathogenicity of Legionella to provide a reference for practical application selection.

关 键 词：军团菌 军团菌病 致病性 检测方法 

分 类 号：R446.5[医药卫生—诊断学]