Strictosidine synthase,an indispensable enzyme involved in the biosynthesis of terpenoid indole andβ-carboline alkaloids  

作　　者：CAO Ning WANG Chang-Hong 

机构地区：[1]The MOE Key Laboratory for Standardization of Chinese Medicines,Shanghai R&D Centre for Standardization of Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《Chinese Journal of Natural Medicines》2021年第8期591-607,共17页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81872933 and 81173119);the National Natural Science Foundation of China and Xinjiang Uygur Autonomous Region of China(No.U1130303);the Technology Cooperation Projects of Science in Shanghai,China(No.20015800100);the Key Project of Ministry of Science and Technology of China(No.2018ZX09731016-004)。

摘　　要：Terpenoid indole(TIAs)andβ-carboline alkaloids(BCAs),such as suppressant reserpine,vasodilatory yohimbine,and antimalarial quinine,are natural compounds derived from strictosidine.These compounds can exert powerful pharmacological effects but be obtained from limited source in nature.the whole biosynthetic pathway of TIAs and BCAs,The Pictet–Spengler reaction catalyzed by strictosidine synthase(STR;EC:4.3.3.2)is the rate-limiting step.Therefore,it is necessary to investigate their biosynthesis pathways,especially the role of STR,and related findings will support the biosynthetic generation of natural and unnatural compounds.This review summarizes the latest studies concerning the function of STR in TIA and BCA biosynthesis,and illustrates the compounds derived from strictosidine.The substrate specificity of STR based on its structure is also summarized.Proteins that contain sixbladed four-strandedβ-propeller folds in many organisms,other than plants,are listed.The presence of these folds may lead to similar functions among organisms.The expression of STR gene can greatly influence the production of many compounds.STR is mainly applied to product various valuable drugs in plant cell suspension culture and biosynthesis in other carriers.

关 键 词：BIOSYNTHESIS Pictet-Spengler reaction β-Carboline alkaloids Strictosidine synthase Terpenoid indole 

分 类 号：R284[医药卫生—中药学] Q819[医药卫生—中医学]