New bisabolane-type phenolic sesquiterpenoids from the marine sponge Plakortis simplex  

作　　者：WANG Jie LIU Li HONG Li-Li ZHAN Kai-Xuan LIN Zheng-Jiang JIAO Wei-Hua LIN Hou-Wen 

机构地区：[1]School of Food and Pharmacy,Zhejiang Ocean University,Zhoushan 316000,China [2]Research Center for Marine Drugs,State Key Laboratory of Oncogenes and Related Genes,Department of Pharmacy,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [3]Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China

出　　处：《Chinese Journal of Natural Medicines》2021年第8期626-631,共6页中国天然药物（英文版）

基　　金：supported by the Fundamental Research Funds for Zhejiang Provincial Universities and Research Institutes(No.2019J00012);the National Natural Science Foundation of China(Nos.U1605221,41906075,81803426,and41576130);the New Shoot Talents Program of Zhejiang Province(No.2019R411020);the Innovative Research Team of Highlevel Local Universities in Shanghai。

摘　　要：Six new bisabolane-type phenolic sesquiterpenoids,including plakordiols A-D(1-4),(7 R,10 R)-hydroxycurcudiol(5)and(7 R,10 S)-hydroxycurcudiol(6)were isolated from the marine sponge Plakortis simplex collected from the South China Sea.Their structures were determined based on extensive analysis of spectroscopic data.Their configurations were assigned by coupling constant analysis,NOESY correlations,and the modified Mosher’s method.Furthermore,their cytotoxic and antibacterial activities were evaluated.

关 键 词：Marine sponge Plakortis simplex Sesquiterpene phenols Plakordiols 

分 类 号：R284[医药卫生—中药学]