孕妇HCMV感染血Free-β-HCG和凝血功能及对不良妊娠结局的预测价值  

Values of blood free-β-HCG and coagulation function indexes in prediction of adverse pregnancy outcomes in pregnant women with HCMV infection

作　　者：朱艳菊[1] 阚长利[1] 付久园[1] 肖艳平[1] 郭艳巍[1] ZHU Yan-ju;KAN Chang-li;FU Jiu-yuan;XIAO Yan-ping;GUO Yan-wei(Affiliated Hospital of Chengde Medical University,Chengde,Hebei 067000,China)

机构地区：[1]承德医学院附属医院产科,河北承德067000

出　　处：《中华医院感染学杂志》2021年第13期2046-2049,共4页Chinese Journal of Nosocomiology

基　　金：承德市科技局科技支撑基金资助项目(201606A033)。

摘　　要：目的探讨孕妇巨细胞病毒(HCMV)感染血游离β人绒毛促性腺激素(Free-β-HCG)、凝血功能及其对不良妊娠结局的预测价值。方法选取2017年10月-2019年12月承德医学院附属医院HCMV感染孕妇62例为感染组,同期健康孕妇62名为对照组。比较两组与感染组不同妊娠结局孕妇一般资料、凝血功能指标[纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、国际标准化比值(INR)]、血Free-β-HCG水平,绘制受试者工作特征曲线(ROC)探讨血各指标预测HCMV感染孕妇不良妊娠结局的价值。结果感染组血FIB水平高于对照组,血APTT、INR、Free-β-HCG水平低于对照组(P<0.05);感染组不同妊娠结局孕妇年龄、孕前体质量、孕周、孕次、孕妇类型相比,无统计学差异;存在不良妊娠结局孕妇血FIB水平高于无不良妊娠结局孕妇,血APTT、INR、Free-β-HCG水平低于无不良妊娠结局孕妇(P<0.05);ROC曲线显示,采用血各指标单一、联合预测均具有较高曲线下面积(AUC),尤以联合预测最高,达0.893。结论HCMV感染孕妇凝血功能、血Free-β-HCG水平均异常改变,且与不良妊娠结局相关,各指标联合检测可提高对HCMV感染发生的预测价值,利于早期干预。OBJECTIVE To explore the values of blood freeβhuman chorionic gonadotropin(Free-β-HCG)and coagulation function indexes in prediction of adverse pregnancy outcomes in the pregnant women with human cytomegalovirus(HCMV)infection.METHODS A total of 62 pregnant women with HCMV infection who were treated in the Affiliated Hospital of Chengde Medical University from Oct 2017 to Dec 2019 were assigned as the infection group,meanwhile,62 healthy pregnant women were set as the control group.The baseline data and levels of blood coagulation indexes[fibrinogen(FIB),activated partial thromboplastin time(APTT),international normalized ratio(INR)]and blood Free-β-HCG were observed and compared between the two groups and among the pregnant women with different pregnancy outcomes in the infection group.Receiver operating characteristic(ROC)curve was drawn to explore the values of the indexes in prediction of adverse pregnancy outcomes of the pregnant women with HCMV infection.RESULTS The blood FIB level of the infection group was significantly higher than that of the control group,and the blood APTT,INR and Free-β-HCG level of the infection group were significantly lower than those of the control group(P<0.05).There were no significant differences in the age,progestational body mass,gestational weeks,gravidity and type of pregnant woman among the pregnant women with different pregnancy outcomes in the infection group.The blood FIB level of the pregnant women with adverse pregnancy outcomes was significantly higher than that of the pregnant women without adverse pregnancy outcomes,while the blood APTT,INR and Free-β-HCG level of the pregnant women with adverse pregnancy outcomes were significantly lower than those of the pregnant women without adverse pregnancy outcomes(P<0.05).ROC curve showed that both single and joint detection of the indexes had large area under curve(AUC),with the joint detection the highest(0.893).CONCLUSION The pregnant women with HCMV infection present with abnormal changes of blood coagulation funct

关 键 词：巨细胞病毒 凝血功能 游离β人绒毛促性腺激素 不良妊娠结局 

分 类 号：R714.231[医药卫生—妇产科学]