Vilsmeier反应在有机合成中的应用  

Application of Vilsmeier Reaction in Organic Synthesis

作　　者：王玲艳 孔祥文[1] 李光辉 WANG Ling-yan;KONG Xiang-wen;LI Guang-hui(College of Science Shenyang University Chemical Technology,Shenyang 110142,Liaoning China)

机构地区：[1]沈阳化工大学理学院,沈阳110142

出　　处：《染料与染色》2021年第4期36-43,共8页Dyestuffs and Coloration

基　　金：辽宁省普通高等教育本科教学改革研究项目(辽教函[2018]471号);沈阳化工大学“双一流”建设标志性成果滚动资助项目。

摘　　要：Vilsmeier反应在有机合成中应用极其广泛,在染料、农药、医药等合成中占有非常重要的地位。Vilsmeier试剂是取代酰胺和卤化物形成的复合物,在其作用下,反应物发生甲酰化、氯甲酰化、芳构化、重排、脱水、环化等反应。本文综述了Vilsmeier试剂、Vilsmeier反应机理以及在染料方面的应用,展望了该反应在未来工业生产的前景。Vilsmeier reaction is widely used in organic synthesis and occupy a very important position in the fields of dyes, pesticides and medicine.Vilsmeier reagent is a compound formed by replacing amides and halides.Under its action, the reactants undergo formylation, chlorinated formylation, aromatization, rearrangement, dehydration, cyclization and other reactions.The Vilsmeier reagent and Vilsmeier reaction mechanism and its application in dye were reviewed, and the prospect of the reaction in industrial production was prospected.

关 键 词：Vilsmeier反应 染料 反应机理 有机合成 

分 类 号：TQ610.1[化学工程—精细化工]