DCE-MRI检查五项参数与类风湿关节炎疾病活动度关系及临床价值  

The Relationship between the Five Parameters of DCE-MRI and the Disease Activity of Rheumatoid Arthritis and Its Clinical Value

作　　者：郑婧[1] 任水明[1] 张凤翔[2] 高倩 高婧 杨永梅 高凯乐 ZHENG Jing;REN Shuiming;ZHANG Fengxiang;GAO Qian;GAO Jing;YANG Yongmei;GAO Kaile(Department of Rheumatology and Nephrology,Ordos Central Hospital,Ordos 017000,Inner Mongolia,P.R.China;Department of Imaging,Ordos Central Hospital,Ordos 017000,Inner Mongolia,P.R.China)

机构地区：[1]鄂尔多斯市中心医院风湿肾脏科,内蒙古鄂尔多斯017000 [2]鄂尔多斯市中心医院影像科,内蒙古鄂尔多斯017000

出　　处：《影像科学与光化学》2021年第5期721-726,共6页Imaging Science and Photochemistry

基　　金：鄂尔多斯市高端卫生健康人才培养项目

摘　　要：探究动态增强磁共振成像(DCE-MRI)检查五项参数与类风湿关节炎(RA)患者疾病活动度的相关性及联合预测近期预后的临床价值。选取105例RA患者作为研究对象,均根据治疗6个月后治疗反应情况分为预后良好组(80例)与预后不良组(25例)。结果发现,DCE-MRI检查参数RE、MRE、ME、Slope max、AUC随疾病活动度增加呈升高趋势,与疾病活动度呈正相关(r=0.759、0.803、0.763、0.666、0.724,P<0.05),与近期预后显著相关;且DCE-MRI检查五项参数联合预测近期预后的AUC为0.937,95%CI为0.872~0.975,P<0.001,敏感度为80.00%,特异度为95.00%,显著优于单独预测。提示采用DCE-MRI检查五项参数可作为临床评估RA病情程度、预测近期预后的可靠手段,为临床提供科学循证依据。The correlation between the five parameters of dynamic contrast enhanced magnetic resonance imaging(DCE-MRI)and the disease activity of patients with rheumatoid arthritis(RA)and the clinical value of joint prediction of short-term prognosis.A total of 105 RA patients were selected as the research objects.They were divided into a good prognosis group(80 cases)and a poor prognosis group(25 cases)according to the treatment response after 6 months of treatment.The results showed that RE,MRE,ME,Slope max and AUC in DCE-MRI showed an increasing trend with the increase of disease activity,and were positively correlated with disease activity(r=0.759,0.803,0.763,0.666,0.724,P<0.05).Significantly related to the short-term prognosis.The five parameters of DCE-MRI examination combined predict the short-term prognosis AUC of 0.937,95%CI of 0.872-0.975,P<0.001,sensitivity of 80.00%,specificity of 95.00%,significantly better than individual forecast.It is suggested that the five parameters of DCE-MRI examination can be used as a reliable method to clinically evaluate the severity of RA and predict the short-term prognosis,and provide a scientific evidence-based basis for the clinic.

关 键 词：类风湿关节炎 疾病活动度 动态增强磁共振成像 近期预后 预测价值 

分 类 号：R593.22[医药卫生—内科学]