急性心肌梗死介入术后肺部感染与外周血IL-17A和IL-23R基因多态性的关联性  

Gene polymorphisms of IL-17A and IL-23R in peripheral blood of acute myocardial infarction patients with pulmonary infection after interventional surgery

作　　者：胡彬[1] 张伟伟[1] 相鹏[1] 罗秀英[1] 童铎 HU Bin;ZHANG Wei-wei;XIANG Peng;LUO Xiu-ying;TONG Duo(The First People's Hospital of Jiande,Jiande,Zhejiang 311600,China)

机构地区：[1]建德市第一人民医院心血管内科,浙江建德311600

出　　处：《中华医院感染学杂志》2021年第14期2179-2183,共5页Chinese Journal of Nosocomiology

基　　金：杭州市科技计划引导基金资助项目(20140733Q53)。

摘　　要：目的分析急性心肌梗死(AMI)冠状动脉介入治疗(PCI)术后肺部感染患者外周血白细胞介素-17A(IL-17A)、白细胞介素-23受体(IL-23R)基因多态性的关联。方法回顾性分析156例建德市第一人民医院心血管内科接受PCI的AMI患者临床资料,其中33例PCI术后7 d内发生肺部感染,纳入感染组,另123例未发生肺部感染患者纳入未感染组;比较两组外周血IL-17A、IL-23R基因多态性,多元逐步回归分析AMI患者外周血IL-17A、IL-23R基因多态性与PCI术后肺部感染的关系。结果PCI术后肺部感染组患者年龄较未感染组患者大(P<0.05);两组外周血IL-17A rs2275913和IL-23R rs6682925位点基因型及等位基因分布差异有统计学意义(P<0.05);多元逐步回归分析显示年龄,IL-17A rs2275913位点AG、GG基因型、G等位基因,IL-23R rs6682925位点CC基因型、C等位基因均与AMI患者PCI术后肺部感染密切相关(P<0.05),且方差膨胀因子(VIF)<3。结论IL-17A rs2275913和IL-23R rs6682925基因多态性是AMI患者PCI术后肺部感染的易感基因型,且年龄与AMI患者PCI术后肺部感染也存在显著相关性。OBJECTIVE To analyze the gene polymorphisms of interleukin-17 A(IL-17 A)and interleukin-23 receptor(IL-23 R)in peripheral blood of acute myocardial infarction(AMI)patients with pulmonary infection after percutaneous coronary intervention(PCI).METHODS The clinical data of 156 AMI patients who received PCI in department of cardiovascular medicine of the First People’s Hospital of Jiande were retrospectively analyzed,33 of whom had pulmonary infection within 7 days after PCI and were assigned as the infection group,123 patients without pulmonary infection were assigned as the non-infection group.The peripheral blood IL-17 A and IL-23 R gene polymorphisms were compared between the two groups,and multivariate stepwise regression analysis was performed for the relationship between the gene polymorphisms of IL-17 A,IL-23 R and the postoperative pulmonary infection in PCI patients.RESULTS The patients with postoperative pulmonary infection were significantly older than those of the patients without infection(P<0.05).There were significant differences in genotypes and allele at peripheral blood IL-17 A rs2275913 and IL-23 R rs6682925 loci between the two groups(P<0.05).Multivariate stepwise regression analysis showed that the postoperative pulmonary infection in AMI patients undergoing PCI was closely associated with the age,IL-17 A rs2275913 locus AG,GG genotypes,allele G,IL-23 R rs6682925 locus CC genotype and allele C(P<0.05),and variance inflation factor(VIF)was less than 3.CONCLUSION The IL-17 A rs2275913 and IL-23 R rs6682925 gene polymorphisms are the susceptible genotypes in the AMI patients with pulmonary infection after PCI,and there is remarkable correlation between the age and the pulmonary infection in the AMI patients after PCI.

关 键 词：急性心肌梗死 冠状动脉介入治疗 肺部感染 白细胞介素-17A 白细胞介素-23受体 

分 类 号：R541.4[医药卫生—心血管疾病]