电动微针联合中药提取物在中重度雄激素性脱发中的临床疗效观察  

Clinical observation of electric microneedle combined with extracts of Chinese traditional medicine in the treatment of moderate to severe androgenic alopecia

作　　者：张凡[1] 冯巾娣 杨一诺 邱婉宁 赵晶辉[1] 万丽 闫颖[1] 潘靖[1] ZHANG Fan;FENG Jin-di;YANG Yi-nuo;QIU Wan-ning;ZHAO Jing-hui;WAN Li;YAN Ying;PAN Jing(Department of Dermatology and Venereology,Beijing Jishuitan Hospital,Beijing City,100035,China;Peking University Health Science Center,School of Clinical Medicine,Beijing City,100191,China)

机构地区：[1]北京积水潭医院皮肤性病科,北京100035 [2]北京大学医学部临床医学院,北京100191

出　　处：《中国医疗美容》2021年第8期55-61,共7页China Medical Cosmetology

摘　　要：目的评价电动微针联合中药提取物治疗中重度雄激素性脱发的治疗效果和安全性。方法于我院皮肤科门诊收集雄激素性脱发男性56例,女性27例,分别采用男性口服非那雄胺,外用5%米诺地尔,域发医用护理包电动微针疗法每周一次;女性口服螺内酯或炔雌醇环丙孕酮片,局部外用2%米诺地尔搽剂,域发医用护理包电动微针疗法每周一次。结果观察12周后,86.7%的患者接受4次及以上治疗(含12次),说明大部分患者能够接受并坚持进行微针治疗。中度脱发患者接受4次及以上治疗的占76.8%,完成12次治疗的占8.7%;重度脱发患者接受4次及以上治疗的占92.8%,完成12次治疗的占50.0%;中度及重度脱发患者完成治疗次数之间的差异具有统计学意义(P<0.01)。接受微针治疗的有效率为100%,随着治疗次数的增加,中度及以上改善患者有增多趋势。每个治疗次数分组内部的中度及重度脱发患者的治疗效果差异无统计学意义(P>0.01),即在相同治疗次数区间内,患者的病情严重程度不影响本试验治疗方案的临床疗效。治疗过程中患者未出现明显不良反应。结论本实验在口服、外用药物基础上联合域发医用护理包电动微针疗法,可显著缩短起效时间,提高治疗效果,值得临床推广使用。Objective To evaluate the therapeutic effect and safety of electric microneedle combined with Chinese traditional medicine extracts in the treatment of moderate to severe androgenic alopecia.Methods 56 males and 27 females with androgenetic alopecia were collected from the Dermatology Clinic of our hospital.The males received oral finasteride,5%minoxidil for external use,and microneedle therapy once a week;females received oral spironolactone or Ethinyl estradiol and cyproterone tablets,topical 2%minoxidil liniment,microneedle therapy once a week.Results After 12 weeks of observation,86.7%of patients received 4 or more treatments(including 12 treatments),indicating that most patients can accept and persist in microneedling treatment.Moderate alopecia patients received 4 or more treatments accounted for 76.8%,completed 12 treatments accounted for 8.7%;severe alopecia patients received 4 or more treatments accounted for 92.8%,completed 12 treatments accounted for 50.0%;moderate and The difference in the number of times of treatment completed by patients with severe alopecia was statistically significant(P<0.01).The effective rate of receiving microneedle treatment is 100%.With the increase in the number of treatments,there is a trend of increasing patients with moderate or above improvement.There was no statistically significant difference in the treatment effect of moderate and severe alopecia patients within each treatment frequency group(P>0.01),that is,within the same treatment frequency interval,the severity of the patient's condition did not affect the clinical efficacy of the treatment plan in this trial.During the treatment,the patient had no obvious adverse reactions.Conclusion This experiment is based on oral and topical drugs combined with the treatment of Yufa microneedles,which can significantly shorten the onset time and improve the treatment effect,and it is worthy of clinical application.

关 键 词：电动微针 中药提取物 雄激素性脱发 中重度 临床疗效观察 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]