超声波靶向微泡击碎技术在心脏病基因治疗中的现状与前景  

Current status and prospect of ultrasonic-targeted microbubble destruction in gene therapy of cardiac disease.

作　　者：黄叶 陈巍(综述)[1] 田海(审校)[1] Huang Ye;Chen Wei;Tian Hai(Department of Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Heilongjinag Province,Harbin 150001, China)

机构地区：[1]哈尔滨医科大学附属第二医院心血管外科,150001

出　　处：《疑难病杂志》2021年第9期948-952,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金面上项目(81770347)。

摘　　要：基因治疗在心脏病治疗中有效地填补了药物、手术等方法远期预后不良、有创等的局限,成为近年来研究的热点。物理、化学、病毒转染等基因转染方式均存在安全性问题,包括组织损伤、细胞毒性、免疫反应等。超声波靶向微泡击碎技术(UTMD)作为基因传递的途径,有无创、安全、靶向的特点。文章就UTMD在心脏病基因治疗中的现状与前景作一综述。Gene therapy in the treatment of heart disease effectively fill the limitations of drugs,surgery and other methods of poor long-term prognosis,such as invasive,has become a research hotspot in recent years.Physical,chemical,viral transfection and other gene transfection methods have safety problems,including tissue damage,cytotoxicity,immune response and so on.Ultrasonic targeted microbubble crushing(UTMD)is a non-invasive,safe and targeted method for gene delivery.This article reviews the present situation and prospect of UTMD in gene therapy of heart disease.

关 键 词：超声波靶向微泡击碎技术 心脏病 基因治疗 

分 类 号：R445.1[医药卫生—影像医学与核医学] R541[医药卫生—诊断学]