零维碳基纳米材料细胞毒性效应的研究进展  

Research advances on the cytotoxic effects of zero-dimensional carbon-based nanomaterials

作　　者：李依檬 刘熙 吴添舒 LI Yi-meng;LIU Xi;WUTian-shu(The Key Laboratory of Environmental Medicine Engineering,School of Public Health,Southeast University,Nanjing 210009,China;School of Medicine,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学公共卫生学院,环境医学工程教育部重点实验室,江苏南京210009 [2]东南大学医学院,江苏南京210009

出　　处：《中国环境科学》2021年第9期4402-4414,共13页China Environmental Science

基　　金：国家自然科学基金(82103884);江苏省基础研究计划(BK20180371);中央高校基本科研业务费专项资金(2242020K40192);东南大学至善青年学者项目(2242020R40140)。

摘　　要：介绍了碳基纳米材料进入细胞的主要途径,重点总结分析了几种常见零维碳基纳米材料导致细胞发生不同形式的死亡效应及其可能的毒作用机制,影响纳米材料毒性的各种理化性质也有所阐述.最后在本课题研究成果的基础上对未来碳基纳米材料的毒性研究前景进行了思考和展望,将为碳基纳米材料设计优化和广泛应用提供有价值的参考.The main pathways of carbon-based nanomaterials entering into cells were introduced in this paper,and the analysis of different forms of cell death caused by several commonly used zero-dimensional carbon-based nanomaterials and their potential toxic mechanisms was focused on.The physical and chemical factors affecting the cell death induced by carbon-based nanomaterials were elaborated as well.Finally,the prospects of toxicity study of carbon-based nanomaterials based on our findings were provided in this review,which benefits the design optimization and wider application of carbon-based nanomaterials in the future.

关 键 词：碳基纳米材料 文献计量学 纳米毒理学 细胞死亡方式 

分 类 号：X503.1[环境科学与工程—环境工程] X171.5