软叶针葵花粉致变应性鼻炎趋化因子及受体变化  

Change of chemokines and receptors of patients with allergic rhinitis induced by pollen of phoenix roebelenii

作　　者：谢伟伟 龙绮[1] 林秀联 蔡琼香 李春林[1] XIE Weiwei;LONG Qi;LIN Xiulian;CAI Qiongxiang;LI Chunlin(Department of Otorhinolaryngology Head and Neck Surgery,Affiliated Haikou Hospital of Xiangya Medical College,Central South University,Haikou,Hainan 570208,China)

机构地区：[1]中南大学湘雅医学院附属海口医院耳鼻咽喉头颈外科,海口570208

出　　处：《重庆医学》2021年第17期2925-2928,共4页Chongqing medicine

基　　金：国家自然科学基金项目(81160129);海南省自然科学基金项目(811145);海南省海口市重点科技计划项目(海科工信立[2012]72号)。

摘　　要：目的探究与分析软叶针葵花粉致变应性鼻炎患者血清趋化因子及受体表达的变化情况。方法选取2018年6月至2020年3月该院70例软叶针葵花粉致变应性鼻炎患者为观察组,选取同时期70例健康同龄者作为对照组。比较两组血清趋化因子[调节活化正常T细胞表达和分泌的趋化因子(RANTES)、胸腺活化调节趋化因子(CCL17)、巨噬细胞源性趋化因子(CCL22)]及其受体[CC趋化因子受体(CCR)3、CCR4及CCR5]表达水平,并比较不同严重程度观察组血清趋化因子及受体表达水平,采用Spearman秩相关分析上述指标与变应性鼻炎严重程度的相关性。结果与对照组比较,观察组RANTES[(431.23±28.76)ng/L vs.(652.66±39.89)ng/L]、CCL17[(553.63±33.76)ng/L vs.(660.72±50.78)ng/L]、CCL22[(653.75±31.32)ng/L vs.(773.63±52.39)ng/L]、CCR3[(1.50±0.20)%vs.(2.72±0.39)%]、CCR4[(9.97±1.52)%vs.(13.73±2.26)%]及CCR5[(12.23±1.39)%vs.(19.31±2.35)%]表达水平更高,且不同严重程度观察组血清趋化因子及受体表达水平比较,差异有统计学意义(P<0.05)。Spearman秩相关分析显示血清趋化因子及受体与变应性鼻炎的严重程度呈正相关(P<0.05)。结论软叶针葵花粉致变应性鼻炎患者血清趋化因子及受体表达水平升高,且与疾病严重程度有相关性。Objective To investigate and analyze the change situation of serum chemokines and receptors expression of patients with allergic rhinitis induced by pollen of phoenix roebelenii.Methods A total of 70 patients with allergic rhinitis induced by pollen of phoenix roebelenii from June 2018 to March 2020 were chosen as the observation group,while 70 healthy persons of the same age at the same time were chosen as the control group.Compared serum chemokines[chemokines that regulate the expression and secretion of activated normal T cells(RANTES),thymus activation regulatory chemokines(CCL17),macrophage-derived chemokines(CCL22)]and their receptors[CC Chemokine Receptor(CCR)3,CCR4 and CCR5]expression levels of the two groups,and the expression levels of serum chemokines and receptors in the observation group with different severity levels.Spearman rank correlation was used to analyze the correlation between the above-indicators and the severity of allergic rhinitis.Results Compared with the control group,RANTES[(431.23±28.76)ng/L vs.(652.66±39.89)ng/L],CCL17[(553.63±33.76)ng/L vs.(660.72±50.78)ng/L],CCL22[(653.75±31.32)ng/L vs.(773.63±52.39)ng/L],CCR3[(1.50±0.20)%vs.(2.72±0.39)%],CCR4[(9.97±1.52)%vs.(13.73±2.26)%]and CCR5[(12.23±1.39)%vs.(19.31±2.35)%]expression levels in the observation group were higher,while the difference was statistically significant in the expression levels of serum chemokines and receptors in the observation group with different severity levels(P<0.05).Spearman rank correlation analysis showed that serum chemokines and receptors were positively correlated with the severity of allergic rhinitis(P<0.05).Conclusion The serum chemokines and receptors of patients with allergic rhinitis induced by pollen of phoenix roebelenii are negatively correlated with severity degree of disease.

关 键 词：软叶针葵花粉 变应性鼻炎 严重程度 血清 趋化因子 趋化因子受体 

分 类 号：R765[医药卫生—耳鼻咽喉科]