血脂异常不同证候患者血清NF-κB、ET-1特点及与证候程度的相关性研究  

Characteristics of serum NF-κB and ET-1 concentrations and their correlation with the degree of syndrome in patients with dyslipidemia of different syndromes

作　　者：安炤泫 赵颖 杨惠民[1] AN Zhaoxuan;ZHAO Ying;YANG Huimin(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学第一临床医学院(东直门医院),北京100700 [2]北京中医药大学第二临床医学院(东方医院),北京100078

出　　处：《现代中西医结合杂志》2021年第25期2746-2749,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：高等学校博士学科点专项科研基金(20110013110002)。

摘　　要：目的探讨血脂异常不同证候患者血清核转录因子-κB(NF-κB)、内皮素-1(ET-1)表达特点及与证候程度的相关性。方法纳入2018年1—7月在北京中医药大学第一临床医学院(东直门医院)住院的血脂异常患者78例,按照中医辨证标准分为脾肾阳虚证组39例和痰浊阻遏证组39例,收集2组人口学资料,采用ELISA法测定2组患者血清NF-κB、ET-1水平,通过中医证候量表进行量化评分,评估患者证候的严重程度,分析血清NF-κB、ET-1水平与中医证候评分的相关性。结果2组患者性别、年龄、体质指数、收缩压、舒张压、心率、呼吸、体温比较差异均无统计学意义(P均>0.05);痰浊阻遏证组患者血清NF-κB、ET-1水平均明显高于脾肾阳虚证组患者(P均<0.05);脾肾阳虚证组和痰浊阻遏证组患者血清NF-κB水平均与各自中医证候积分呈正相关(r=0.340,P<0.05;r=0.682,P<0.001)。结论血脂异常脾肾阳虚证和痰浊阻遏证患者的血清NF-κB、ET-1水平可以一定程度上反映各自证候特点,NF-κB水平能一定程度上反映患者的证候严重程度,上述特点可为标准化、客观化辨证提供依据。Objective It is to discuss the expression characteristics of serum nuclear factor-κB(NF-κB)and endothelin-1(ET-1)concentrations in patients with dyslipidemia of different syndromes and their correlation with the degree of syndromes.Methods A total of 78 patients with dyslipidemia who were hospitalized in the First Clinical College of Beijing University of Chinese Medicine(Dongzhimen Hospital)from January to July 2018 were enrolled,and were divided into spleen-kidney yang deficiency syndrome group and phlegm-turbidity obstructing syndrome group according to traditional Chinese medical syndrome differentiation standards,39 cases in each group.The demographic data of the two groups were collected,the levels of serum NF-κB and ET-1 of the patients in the two groups were measured by ELISA,the patients was evaluated quantitatively by the TCM Syndrome Scale to evaluated the symptom severity,and the correlation of serum NF-κB and ET-1 level with TCM syndrome score were analyzed.Results There was no significant difference in gender,age,body mass index,systolic blood pressure,diastolic blood pressure,heart rate,respiration,and body temperature between the two groups(all P>0.05);the levels of serum NF-κB and ET-1 in the phlegm-turbid obstructing syndrome group were significantly higher than those in the spleen-kidney yang deficiency group(all P<0.05);the serum NF-κB levels in the spleen-kidney yang deficiency group and the phlegm-turbid obstructing group were positively correlated with their TCM syndrome scores(r=0.340,P<0.05;r=0.682,P<0.001).Conclusion The levels of serum NF-κB and ET-1 patients with dyslipidemia with spleen-kidney yang deficiency syndrome and phlegm-turbid obstructing syndrome can reflect the characteristics of the respective syndromes to a certain extent,and the NF-κB level can reflect the severity of the patients’syndromes to a certain extent.These features can provide a basis for standardized and objective traditional Chinese medical syndrome differentiation for this disease.

关 键 词：血脂异常 脾肾阳虚证 痰浊阻遏证 核转录因子-ΚB 内皮素-1 

分 类 号：R259[医药卫生—中西医结合]