消痛化瘀硬膏治疗冲任失调型乳腺增生病疗效观察  

Observation on the curative effect of Xiaotong Huayu plasteron breast hyperplasia with disharmony of thoroughfare-controlling vessels

作　　者：徐留燕 程旭锋[2] 王伟[2] 王蓓蓓 孟冰心 XU Liuyan;CHENG Xufeng;WANG Wei;WANG Beibei;MENG Bingxin(Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan,China;The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan,China)

机构地区：[1]河南中医药大学,河南郑州450000 [2]河南中医药大学第一附属医院,河南郑州450000

出　　处：《现代中西医结合杂志》2021年第26期2886-2890,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：2017年河南省中医管理局中医临床研究基地科研专项课题(2017JDZX017);2018年河南省中医药科学研究专项课题(2018ZY2089);全国名老中医药专家王万林教授传承工作室(CZ0175)。

摘　　要：目的探讨消痛化瘀硬膏治疗冲任失调型乳腺增生病的临床疗效。方法采用随机、双盲、安慰剂对照的研究方法,选取2019年1月—2020年6月在河南中医药大学第一附属医院乳腺病科门诊就诊的女性冲任失调型乳腺增生病患者150例,按照计算机随机数字法分为治疗组和对照组,每组75例。治疗组患者予以消痛化瘀硬膏治疗,对照组予以安慰剂硬膏治疗。2组均将硬膏贴敷于双侧乳腺最痛处或肿块或结节处,晚上睡前贴敷1次,每次6~8 h,隔日1次,经期停用,连续用药8周。观察比较2组治疗前及治疗8周后乳房疼痛总积分、乳腺彩超评分、抑郁评分及孕激素(P)、雌二醇(E2)、垂体泌乳素(PRL)水平的变化,比较2组中医证候疗效及治疗期间不良反应发生情况。结果2组治疗后乳房疼痛总积分、抑郁评分均显著降低(P均<0.05),且治疗后治疗组明显低于对照组(P均<0.05);治疗后治疗组乳腺彩超评分明显低于治疗前及对照组(P均<0.05),对照组乳腺彩超评分无明显变化(P>0.05);治疗后治疗组E2、PRL水平明显低于治疗前及对照组(P均<0.05),P水平明显高于治疗前及对照组(P均<0.05),对照组治疗后上述指标均无明显变化(P均>0.05)。治疗组总有效率为91.7%(66/72),对照组总有效率为37.1%(26/70),2组比较差异有统计学意义(P<0.05);2组治疗期间均未发生严重的全身不良反应,均未见明显肝肾损伤。结论消痛化瘀硬膏可消除或减轻冲任失调型乳腺增生病患者的乳房疼痛,降低乳腺彩超评分,改善抑郁情绪,调控激素水平,改善中医证候,疗效显著,不良反应少。Objective It is to explore the clinical efficacy of Xiaotong Huayu plaster in the treatment of breast hyperplasia with disharmony of thoroughfare-controlling vessels.Methods A total of 150 female patients with breast hyperplasia with disharmony of thoroughfare-controlling vessels who were admitted to the Department of Breast Diseases of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2019 to June 2020 were selected by a randomized,double-blind,placebo-controlled research method and divided into treatment group(n=75)and control group(n=75)by random number method.The patients in the treatment group were treated with Xiaotong Huayu plaster,while the control group was treated with placebo plaster.The plasters were applied to the most painful areas or lumps or nodules of the breasts in both groups,applied at night before going to bed application for 6 to 8 hours each time,once every other day,stopped in the menstrual period,and the medication was continued for 8 weeks.The changes in the total scores of breast pain,breast color Doppler ultrasound score,depression score,and the levels of estradiol(E2),progesterone(P),pituitary prolactin(PRL)before and after treatment were compared in the two groups,and the curative effect of traditional Chinese medical syndrome and the occurrence of adverse reactions during the treatment were compared between the two groups.Results The breast pain scores and depression scores of the two groups were significantly reduced after treatment(both P<0.05),and the treatment group was significantly lower than the control group(P<0.05);the breast color ultrasound scores of the treatment group after treatment were significantly lower than those before treatment and in the control group(P<0.05),the breast color ultrasound score of the control group did not change significantly(P>0.05);after treatment,the E2 and PRL levels of the treatment group were significantly lower than those before treatment and in the control group(P<0.05),and the P level was sig

关 键 词：消痛化瘀硬膏 冲任失调 乳腺增生病 中医外治 

分 类 号：R655.8[医药卫生—外科学]