和化定喘方治疗气虚血瘀痰阻型稳定期COPD疗效及对炎性因子、免疫功能的影响  

Efficacy of Hehua Dingchuan Decoction on stable COPD with syndrome of Qi deficiency,blood stasis and phlegm stagnation and its effect on inflammatory factors and immune function

作　　者：李川 张其慧[1] 张文娜[1] 窦进[1] 王曦 LI Chuan;ZHANG Qihui;ZHANG Wenna;DOU Jin;WANG Xi(Huguosi Hospital of Traditional Chinese Medicine Affiliated to Beijing University of Chinese Medicine, Beijing 100035, China)

机构地区：[1]北京中医药大学附属护国寺中医医院,北京100035

出　　处：《现代中西医结合杂志》2021年第26期2891-2896,2930,共7页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家中医药管理局——许彭龄全国名老中医药专家传承工作室(国中医药人教发〔2011〕41号);北京市西城区卫生健康委员会青年科技人才培养项目(XWKX2020-03)。

摘　　要：目的探讨和化定喘方治疗气虚血瘀痰阻型稳定期慢性阻塞性肺疾病(COPD)的疗效及对炎性因子、免疫功能的影响。方法选取2019年6月—2020年12月北京中医药大学附属护国寺中医医院中医内科门诊及病房治疗的气虚血瘀痰阻型稳定期COPD患者110例作为研究对象,按就诊先后顺序编号,用随机数字表法将患者分为治疗组、对照组各55例。对照组予西医常规治疗,治疗组在对照组治疗基础上予和化定喘方治疗,2组均治疗28 d。比较2组患者治疗后的临床疗效;观察2组治疗前后6 min步行试验、改良英国医学研究学会呼吸困难指数(mMRC)、慢阻肺评估测试评分(CAT)、第1秒用力呼气容积占预计值的百分比(FEV1%)、第1秒用力呼气容积(FEV1)/用力肺活量(FVC)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、CD4+、CD8+、CD4+/CD8+水平的变化情况。结果治疗28 d后,试验组总有效率为92.45%(49/53),对照组总有效率为80.39%(41/51),试验组疗效明显好于对照组,差异有统计学意义(P<0.05);试验组治疗后6 min步行距离明显长于对照组(P<0.05),FEV1%、FEV1/FVC、CD4+、CD4+/CD8+水平均明显高于对照组(P均<0.05),mMRC评分、CAT及血清IL-6、IL-8、CD8+水平均明显低于对照组(P均<0.05)。结论和化定喘方治疗气虚血瘀痰阻型稳定期COPD疗效确切,可以改善患者的临床症状及呼吸困难程度,提高运动耐力,减轻气流阻塞,抑制气道炎症反应,调节免疫失衡。Objective It is to investigate the curative effect of Hehua Dingchuan Decoction on stable chronic obstructive pulmonary disease(COPD)with syndrome of Qi deficiency,blood stasis and phlegm stagnation and its effect on inflammatory factors and immune function.Methods A total of 110 patients with stable COPD with syndrome of Qi deficiency,blood stasis and phlegm stagnation treated in the TCM internal medicine outpatient department and wards of Huguosi Hospital of Traditional Chinese Medicine from June 2019 to December 2020 were selected as the research subjects.They were numbered according to the order of visit,and divided into the treatment group and the control group with 55 cases in each group by random number table method.The control group was treated with conventional western medicine,and the treatment group was treated with Hehua Dingchuan Decoction on the basis of the control group.Both groups were treated for 28 days.The clinical efficacy after treatment was compared between the two groups.The changes in the 6-minute walk test,modified British medical research council(mMRC),COPD assessment test(CAT),forced expiratory volume in the first second as a percentage of the predicted value(FEV1%),forced expiratory volume in the first second(FEV1)/forced vital capacity(FVC),and the levels of interleukin-6(IL-6),IL-8,CD4+,CD8+,CD4+/CD8+were observed before and after treatment in the two groups.Results After 28 days of treatment,the total effective rate of the treatment group was 92.45%(49/53),and the total effective rate of the control group was 80.39%(41/51),the efficacy of the treatment group was significantly better than that of the control group,the difference was statistically significant(P<0.05).The six-minute walking distance after treatment in the experimental group was significantly longer than that in the control group(P<0.05),and the levels of FEV1%,FEV1/FVC,IL-6,CD4+,CD4+/CD8+were significantly higher than those in the control group(P<0.05),the scores of mMRC and CAT and the levels of serum IL-6,IL-8 and C

关 键 词：稳定期慢性阻塞性肺疾病 气虚血瘀痰阻 和化定喘方 

分 类 号：R563.3[医药卫生—呼吸系统]