壮医药线点灸疗法的实验研究进展  

Experimental Research Progress of Thread-Point Moxibustion Therapy in Zhuang Medicine

作　　者：钟海森 覃骊兰[1] 刘真真 蓝毓营[1] ZHONG Haisen;QIN Lilan;LIU Zhenzhen;LAN Yuying(Guangxi University of Chinese Medicine,Nanning Guangxi China 530200)

机构地区：[1]广西中医药大学,广西南宁530200

出　　处：《中医学报》2021年第9期1898-1903,共6页Acta Chinese Medicine

基　　金：国家重点研发计划项目(2017YFC1703903)。

摘　　要：壮医药线点灸疗法具有抗炎止痛、抗氧化、抗衰老、增强免疫力、改善失眠、降血糖血压、抗肝纤维化、调节神经系统功能等药理作用。该疗法能够通过调控前列腺素F2α(prostaglandin F2α,PGF2α)、NOX4、红细胞沉降率(erythrocyte sedimentation rate, ESR)、C-反应蛋白(C-reactive protein, CRP)、白细胞介素-17(interleukin-17,IL-17)、IL-23、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、IL-1β等相关因子的合成与分泌,缓解痛症,抑制炎症反应,减轻哮喘症状,改善血液流变学指标,降低血糖水平,广泛应用于临床治疗女性痛经、坐骨神经痛、带状疱疹后遗神经痛、关节炎、哮喘、抑郁症、失眠、斑秃、糖尿病等疾病。但目前壮医药线点灸疗法的实验研究较少涉及分子机制方面,多停留在组织水平,且动物实验的可重复性、标准性有待加强,今后需加强随机对照双盲的大样本临床研究,建立与人类疾病高度吻合的实验动物模型以及可重复的中医病证模型,提高实验数据的可靠性。Thread-point moxibustion therapy in Zhuang medicine has pharmacological effects such as anti-inflammatory and analgesic, anti-oxidation, anti-aging, enhancing immunity, improving insomnia, reducing blood glucose and blood pressure, anti-liver fibrosis, regulating nervous system function and so on.The therapy can regulate prostaglandin F2α(PGF2α),NOX4,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),interleukin-17(IL-17),IL-23,tumor necrosis factor-α(TNF-α),IL-1β synthesis and secretion of related factors, alleviate pain, inhibit inflammatory response, reduce asthma symptoms, improve hemorheological indexes and reduce blood glucose level.It is widely used in clinical treatment of female dysmenorrhea, sciatica, postherpetic neuralgia, arthritis, asthma, depression, insomnia, alopecia areata, diabetes and other diseases.However, at present, the experimental research on thread-point moxibustion therapy in Zhuang medicine rarely involves the molecular mechanism, mostly stays at the tissue level, and the repeatability and standardization of animal experiments need to be strengthened.In the future, it is necessary to strengthen the randomized controlled double-blind large sample clinical research, and establish an experimental animal model highly compatible with human diseases and a repeatable TCM syndrome model to improve the reliability of experimental data.

关 键 词：线点灸 壮医药 动物实验 临床试验 文献综述 

分 类 号：R245.8[医药卫生—针灸推拿学]