血清脂蛋白相关磷脂酶A2、核苷酸结合寡聚化结构域样受体蛋白3与老年冠心病Syntax积分的相关性  

Correlation Between the Changes of Serum Lipoprotein-Associated Phospholipase 2, Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Levels and the Syntax Scores in Older Patients with Coronary Atherosclerotic Heart Disease

作　　者：李自平[1] 刘湛[1] LI Ziping;LIU Zhan(Department of Laboratory Medicine,Puyang People’s Hospital,Puyang 457000,China)

机构地区：[1]濮阳市人民医院检验科,河南濮阳457000

出　　处：《河南医学研究》2021年第25期4690-4692,共3页Henan Medical Research

摘　　要：目的探讨血清核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)、脂蛋白相关磷脂酶A2(Lp-PLA_(2))与老年冠心病患者Syntax积分的相关性。方法选取2018年1月至2020年4月濮阳市人民医院收治的114例冠心病患者作为观察组,再选取同期在濮阳市人民医院接受体检的108例健康者作为对照组。比较两组血清NLRP3、Lp-PLA_(2)水平,比较Syntax积分及主要不良心血管事件(MACE)发生情况,比较不同Syntax积分及不同MACE发生情况患者的血清NLRP3、Lp-PLA_(2)水平,分析血清NLRP3、Lp-PLA_(2)水平与Syntax积分的相关性以及血清NLRP3、Lp-PLA_(2)联合检测对发生MACE的预测价值。结果观察组血清NLRP3、Lp-PLA_(2)水平高于对照组(P<0.05)。随着Syntax积分升高,血清NLRP3、Lp-PLA_(2)水平逐渐升高(P<0.05);血清NLRP3、Lp-PLA_(2)水平与Syntax积分呈正相关(P<0.05);发生MACE患者血清NLRP3、Lp-PLA_(2)水平高于对照组(P<0.05);ROC曲线显示血清NLRP3、Lp-PLA_(2)水平联合检测的AUC值大于任意单一检测(P<0.05)。结论冠心病患者血清NLRP3、Lp-PLA_(2)水平升高,其水平与病变严重程度密切相关。通过检测NLRP3、Lp-PLA_(2)水平可预测冠心病患者MACE的发生风险。Objective To explore the relationship between serum nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3),lipoprotein-associated phospholipase A_(2)(Lp-PLA_(2))levels and the syntax scores in older patients with coronary atherosclerotic heart disease(CAHD).Methods A total of 114 patients with CAHD who were treated in Puyang People’s Hospital from January 2018 to April 2020 were selected as the observation group,and a total of 108 healthy persons who accepted physical examination in Puyang People’s Hospital during the same period were selected as the control group.The serum NLRP3 and Lp-PLA_(2) levels of the two groups were compared,the serum NLRP3 and Lp-PLA_(2) levels of patients with different Syntax scores and the occurrence of major adverse cardiovascular events(MACE)were compared,the correlation between the serum NLRP3,Lp-PLA_(2) levels and the Syntax scores was analyzed.The predictive value of combined detection of serum NLRP3 and Lp-PLA_(2) in the occurrence of MACE were analyzed.Results The serum NLRP3 and Lp-PLA_(2) levels of the observation group were higher than those of the control group(P<0.05).As the Syntax score increased,the serum NLRP3 and Lp-PLA_(2) levels gradually increased(P<0.05).The serum NLRP3 and Lp-PLA_(2) levels were positively correlated with Syntax score(P<0.05).Serum NLRP3 and Lp-PLA_(2) levels of MACE patients were higher than those of the control group(P<0.05).ROC curve showed that the AUC value of combined detection of serum NLRP3 and Lp-PLA_(2) levels was greater than that of any single detection(P<0.05).Conclusion The levels of serum NLRP3 and Lp-PLA_(2) in patients with CAHD are increased,and closely related to the degree of disease.The detection of their levels can predict the occurrence of MACE in patients with CAHD.

关 键 词：SYNTAX积分 核苷酸结合寡聚化结构域样受体蛋白3 老年患者 脂蛋白相关磷脂酶A_(2) 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]