滋水清肝饮加减治疗围绝经期慢性便秘临床研究  

Clinical Study of Modified Water-Moistening and Liver-Clearing Beverage on Perimenopausal Chronic Constipation

作　　者：肖倩[1] 黄业保 王秋玲[1] 刘春强[1] XIAO Qian;HUANG Ye-bao;WANG Qiu-ling;LIU Chun-qiang(Liuzhou People′s Hospital,Liuzhou,Guangxi,China,545006)

机构地区：[1]柳州市人民医院,广西柳州545006

出　　处：《河南中医》2021年第9期1376-1380,共5页Henan Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81360545,82060866);广西壮族自治区自然科学基金项目(2017GXNSFAA198119);广西壮族自治区中医药管理局项目(GZZC2020380)。

摘　　要：目的:观察滋水清肝饮治疗围绝经期慢性便秘的临床疗效。方法:将74例围绝经期慢性便秘患者按照随机数字表法分为治疗组和对照组,每组各37例。治疗组给予滋水清肝饮治疗,对照组给予普芦卡必利口服治疗。比较两组患者治疗前后症状积分、汉密尔顿抑郁量表(Hamilton Depression Scale, HAMD)评分及性激素水平[促卵泡激素(follicle-stimulating hormone, FSH)、雌二醇(estradiol, E2)、黄体生成素(luteinizing hormone, LH)]变化情况,比较两组患者临床疗效、复发率及结肠传输试验肠道内标记物残留数量。结果:两组患者治疗后症状积分、HAMD评分低于本组治疗前,且治疗组低于对照组,差异具有统计学意义(P<0.05)。对照组有效率为72.97%,治疗组有效率为89.19%,两组有效率比较,差异具有统计学意义(P<0.05)。两组患者口服胶囊48 h和72 h肠道内标记物残留数量少于本组口服胶囊0 h及24 h,治疗组口服胶囊48 h和72 h肠道内标记物残留数量少于同期对照组,差异具有统计学意义(P<0.05)。治疗后,治疗组E2水平高于本组治疗前及对照组治疗后,FSH、LH低于本组治疗前及对照组治疗后,差异具有统计学意义(P<0.05)。治疗组复发率为21.21%,对照组复发率为51.85%,两组患者复发率比较,差异具有统计学意义(P<0.05)。结论:滋水清肝饮治疗围绝经期慢性便秘,能有效缓解患者便秘症状及抑郁情绪,改善患者性激素水平。Objective: To observe the clinical curative effect of Modified Water-Moistening and Liver-Clearing Beverage on perimenopausal chronic constipation.Methods: A total of 74 patients with perimenopausal chronic constipation were randomly divided into the treatment group and the control group, with 37 cases in each group.The treatment group was treated with Water-Moistening and Liver-Clearing Beverage, while the control group was treated with prucalpride.The symptom score, Hamilton Depression Scale(HAMD) score and the changes of hormone levels [including follicle stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH)] were compared between the two groups before and after treatment.The clinical efficacy, recurrence rate and the number of intestinal marker residues after oral administration after treatment were also compared between the two groups.Results: After treatment, the symptom score and HAMD score of the two groups were lower than those of the same group before treatment, and the above indexes of the treatment group were lower than those of the control group, and all the differences were statistically significant(P<0.05).The effective rate of the control group was 72.97%,and that of the treatment group was 89.19%.The difference between the two groups was statistically significant(P<0.05).After 48 h and 72 h of oral administration, the number of intestinal marker residues in the two groups was less than that at 0 h and 24 h of oral administration.The number of intestinal marker residues in the treatment group was less than that in the control group at 48 h and 72 h after oral administration, and the difference was statistically significant(P<0.05).After treatment, E2 level of the treatment group was higher than that of the same group before treatment and that of the control group after treatment, while FSH and LH of the treatment group were lower than those of the same group before treatment and those of the control group after treatment, and all the differences were statistically significant(P<0.05).The

关 键 词：围绝经期 慢性便秘 滋水清肝饮 

分 类 号：R271.911.75[医药卫生—中西医结合]