基于脑网络的脑疲劳对不同工作记忆负荷的影响  

Effect of Mental Fatigue on Different Working Memory Loads Based on Brain Network

作　　者：杨硕[1,2] 江文涛 王磊[1,2] 徐桂芝[1,2] Yang Shuo;Jiang Wentao;Wang Lei;Xu Guizhi(State Key Laboratory of Reliability and Intelligence of Electrical Equipment,Hebei University of Technology,Tianjin 300130,China;Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering,Hebei University of Technology,Tianjin 300130,China)

机构地区：[1]河北工业大学省部共建电工装备可靠性与智能化国家重点实验室,天津300130 [2]河北工业大学河北省生物电磁与神经工程重点实验室,天津300130

出　　处：《中国生物医学工程学报》2021年第4期446-452,共7页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(51877067)。

摘　　要：工作记忆是认知行为的基础,脑疲劳会导致记忆力衰退、反应迟钝等认知表现下降的现象。利用N-back实验范式设计脑疲劳实验,采集15名被试正常态和疲劳态下4种工作记忆负荷的脑电数据,使用互信息算法构建功能性脑网络,计算并分析节点度、节点中间中心度、节点聚类系数、节点特征路径长度4个网络特征参数,对行为学数据(反应时间、正确率)进行统计分析。结果表明,4种工作记忆负荷下,疲劳态下的脑网络相对于正常态下的脑网络节点度减小,节点中间中心度减小,节点聚类系数减小,节点特征路径长度增大,且具有显著差异节点主要分布于额叶、顶叶和枕叶。行为学数据结果显示,正常态下4种工作记忆负荷的平均反应时间分别为(578±46)、(664±45)、(868±44)、(959±42)ms,疲劳态下4种工作记忆负荷平均反应时间分别为(656±41)、(721±46)、(941±50)、(1038±50)ms,平均反应时间疲劳态显著高于正常态(P<0.05),提示脑疲劳对4种负荷下的工作记忆产生消极影响。在所施加的4种工作记忆负荷下,脑疲劳对工作记忆产生一定影响,会抑制大脑活跃度的提高,且对高负荷的影响比低负荷的影响更明显。Working memory is the basis of cognitive behavior.Brain fatigue can lead to the decline in cognitive performance such as memory decline and slow response.In this paper,the brain fatigue experiment was designed by using the character N-back experimental paradigm.The electroencephalogram data of four kinds of visual working memory load were collected from 15 subjects under normal and fatigue conditions and functional brain network was constructed by using mutual information algorithm.Four network characteristic parameters including node degree,node intermediate center degree,node clustering coefficient and node feature path length were calculated and analyzed.The behavior data(reaction time,correct rate)were statistically analyzed.Results showed that under the four working memory loads,compared with the normal state,the brain network node degree in the fatigue state,the centrality of the node and the node clustering coefficient decreased,and the node characteristic path length increased.The nodes with significant differences were mainly distributed in the frontal lobe,parietal lobe and occipital lobe.Results of behavioral data showed that in the normal state,the average response times of the four working memory loads were(578±46),(664±45),(868±44)and(959±42)ms.In the fatigue state,the average response times of the four working memory loads were(656±41),(721±46),(941±50)and(1038±50)ms.The average response time of fatigue state was significantly higher than that of the normal state,and brain fatigue had a negative effect on the working memory under the 4 loads.The research results showed that under the four working memory loads,the brain fatigue had a certain effect on the working memory.In conclusion,the brain fatigue inhibited the increase of brain activity,and brain fatigue had a more obvious effect on the high load than on the low load.

关 键 词：脑疲劳 脑电 工作记忆 脑网络 

分 类 号：R318[医药卫生—生物医学工程]