丹参离子导入对糖尿病全视网膜光凝后中心凹厚度变化的影响  

Effect of Salvia Iontophoresis on Foveal Thickness Changes after Diabetic Panretinal Photocoagulation

作　　者：林莹[1] 黎绮雯[1] 林小媚[1] 吴小桃[1] 凌梓韵 LIN Ying;LI Qi-Wen;LIN Xiao-Mei;WU Xiao-Tao;LING Zi-Yun(Department of 0phthalmology,Panyu District Hospital of Traditional Chinese Medicine,Guangzhou,Guangdong,511400)

机构地区：[1]广东省广州市番禺区中医院眼科,511400

出　　处：《岭南急诊医学杂志》2021年第4期385-387,共3页Lingnan Journal of Emergency Medicine

基　　金：广东省中医药局科研项目(20201279)。

摘　　要：目的:分析丹参离子导入对糖尿病全视网膜光凝后中心凹厚度变化的影响。方法:选取2020年4月-2021年4月在我院行全视网膜光凝(PRP)治疗的患者60例为研究对象,采用随机分组的方法,分为实验组30例及空白对照组30例。实验组予注射用丹参(冻干)离子导入,空白对照组予氯化钠注射液导入。实验激光治疗前、治疗后4周两组患者最佳矫正视力、平均视野缺损面积和黄斑中心凹厚度的改变。结果:实验组治疗后4周最佳矫正视力高于对照组(P<0.05);实验组治疗后4周平均视野缺损面积小于对照组(P<0.05);实验组治疗后4周黄斑中心凹厚度小于对照组(P<0.05)。结论:注射用丹参(冻干)有可能通过类似抗VEGF作用,使DR患者视网膜激光后黄斑反应减轻、提高PRP术后后中心视力,减轻视网膜激光光凝对视野的损害。Objective:To analyze the effect of Danshen iontophoresis on the change of foveal thickness after diabetic panretinal photocoagulation. Methods:A total of 60 patients who underwent panretinal photocoagulation(PRP)treatment in our hospital from April 2020 to April 2021 were selected as the research objects. Using the method of random grouping,they were divided into an experimental group of 30 cases and a blank control group of 30 cases. The experimental group was injected with Salvia miltiorrhiza(lyophilized)iontophoresis,and the blank control group was injected with sodium chloride injection. The changes in the best corrected visual acuity,the average visual field defect area and the thickness of the fovea of the two groups of patients before experimental laser treatment and 4 weeks after treatment. Results:The best corrected visual acuity of the experimental group 4 weeks after treatment was higher than that of the control group(P<0.05);the average visual field defect area of the experimental group 4 weeks after treatment was smaller than that of the control group(P<0.05);the thickness of the fovea of the experimental group 4 weeks after treatment Less than the control group(P<0.05). Conclusion:Salvia miltiorrhiza for injection(freeze-dried)may reduce the macular response after laser retinal laser,improve the central visual acuity after PRP,and reduce the damage to the visual field caused by laser photocoagulation in DR patients through similar anti-VEGF effects.

关 键 词：丹参离子 糖尿病 全视网膜光凝 

分 类 号：R276.7[医药卫生—中医五官科学]