七叶皂甙钠减少胃旁路手术治疗2型糖尿病术后胃瘫发生的临床研究  

Clinical Study of Sodium Aescinate in Reducing Gastric Paralysis after Gastric Bypass Surgery for Type 2 Diabetes Mellitus

作　　者：童艳兰 甄敬辉 张苗[1] 周金强[1] 李扬[1] 王辉[1] 刘增亮[1] TONG Yanlan;ZHEN Jinghui;ZHANG Miao;ZHOU Jinqiang;LI Yang;WANG Hui;LIU Zengliang(Zhuozhou City Hospital,Zhuozhou 072750,China;不详)

机构地区：[1]河北省涿州市医院,河北涿州072750

出　　处：《中国医学创新》2021年第21期179-182,共4页Medical Innovation of China

基　　金：保定市科学计划与发展指导计划项目(14ZF089)。

摘　　要：目的:探讨七叶皂甙钠减少胃旁路手术治疗2型糖尿病术后胃瘫发生的临床应用效果。方法:选取2016年1月-2018年12月涿州市医院实施胃旁路手术治疗的180例2型糖尿病患者进行研究,所有患者均采用胃旁路手术治疗,根据术后治疗方式不同将患者分为研究组和对照组,各90例。对照组术后采用常规治疗,研究组在对照组基础上加用七叶皂甙钠治疗。观察两组治疗前后胃肠激素水平、术后胃瘫和不良反应发生情况。结果:两组治疗前血浆胃动素和胃泌素水平、胃排空率和胃排空时间比较,差异均无统计学意义(P>0.05);研究组治疗后血浆胃动素和胃泌素水平、胃排空率和胃排空时间均明显优于对照组,差异均有统计学意义(P<0.05)。研究组胃瘫发生率为2.22%,显著低于对照组的11.11%,差异有统计学意义(P<0.05)。研究组未发生过敏性休克、药疹、肝功能损害、急性肾衰竭、心脏异常等严重不良反应。结论:胃旁路手术治疗2型糖尿病术后应用七叶皂甙钠可降低术后胃瘫的发生率,且未明显增加不良反应发生率,临床应用安全有效,值得临床提高应用。Objective:To investigate the clinical effect of Sodium Aescinate in reducing gastric paralysis after gastric bypass surgery for type 2 diabetes mellitus.Method:A total of 180 patients with type 2 diabetes mellitus who underwent gastric bypass surgery in Zhuozhou Hospital from January 2016 to December 2018 were studied,according to the different treatment methods,180 patients were randomly divided into the study group and the control group,90 cases in each group.The control group was treated with routine treatment,and the study group was treated with Sodium Aescinate on the basis of the control group.The levels of gastrointestinal hormones before and after treatment,postoperative gastroparesis and adverse reactions of two groups were observed.Result:There were no significant differences in plasma motilin and gastrin levels,gastric emptying rate and gastric emptying time between two groups before treatment (P>0.05).The levels of plasma motilin and gastrin,gastric emptying rate and gastric emptying time in the study group were significantly better than those in the control group after treatment,and the differences were statistically significant (P<0.05).The incidence of gastroparesis in the study group was 2.22%,which was significantly lower than 11.11% in the control group,and the difference was statistically significant (P<0.05).No serious adverse reactions such as anaphylactic shock,drug eruption,liver function damage,acute renal failure or cardiac abnormality were found in the study group.Conclusion:The use of Sodium Aescinate after gastric bypass surgery for type 2 diabetes mellitus can reduce the incidence of postoperative gastric paralysis,the incidence of adverse reactions is not increased significantly,and the clinical application is safe and effective,which is worth of improving clinical application.

关 键 词：七叶皂甙钠 胃旁路手术 2型糖尿病 胃瘫 

分 类 号：R269[医药卫生—中西医结合]