高压氧辅助硝苯地平联合硫酸镁对妊娠期高血压疾病患者妊娠结局及血管内皮功能的影响  

Effect of Hyperbaric Oxygen Assisted Nifedipine Combined with Magnesium Sulfate on Pregnancy Outcome and Vascular Endothelial Function in Patients with Hypertensive Disorder Complicating Pregnancy

作　　者：杨宏[1] YANG Hong(Jiamusi Maternal and Child Health Care Hospital,Jiamusi 154000,China)

机构地区：[1]黑龙江省佳木斯市妇幼保健院,黑龙江佳木斯154000

出　　处：《中国医学创新》2021年第22期69-73,共5页Medical Innovation of China

摘　　要：目的:探讨高压氧辅助硝苯地平联合硫酸镁对妊娠期高血压疾病患者的疗效及对患者妊娠结局和血管内皮功能的影响。方法:选取2018年2月-2019年1月本院诊治的128例妊娠期高血压疾病患者,根据随机数字表法分为观察组和对照组,每组64例。两组患者均给予常规治疗,对照组给予硫酸镁和硝苯地平联合治疗,观察组在对照组的基础上给予高压氧治疗。比较两组疗效、妊娠结局及治疗前后的血压[收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)]和血管内皮功能指标[血浆内皮素(ET-1)、血管性血友病因子(vWF)、一氧化氮(NO)]水平。结果:观察组总有效率为89.06%高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗前,两组SBP、DBP、MAP、ET-1、NO、vWF比较,差异均无统计学意义(P>0.05);治疗后,两组SBP、DBP、MAP、ET-1、vWF均低于治疗前,NO均高于治疗前,且观察组SBP、DBP、MAP、ET-1、vWF均低于对照组,NO高于对照组,差异均有统计学意义(P<0.05)。观察组自然分娩率为71.88%高于对照组的42.19%,差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率为18.75%低于对照组的39.06%,差异有统计学意义(P<0.05)。结论:高压氧辅助硝苯地平联合硫酸镁治疗妊娠期高血压疾病患者的效果较好,可改善血压和血管内皮功能,不良妊娠结局发生率下降。Objective:To investigate the effect of hyperbaric oxygen assisted Nifedipine combined with Magnesium Sulfate on pregnancy outcome and vascular endothelial function in patients with hypertensive disorder complicating pregnancy.Method:A total of 128 patients with hypertensive disorder complicating pregnancy who came to our hospital for diagnosis and treatment from February 2018 to January 2019 were selected,and they were divided into observation group and control group according to the random number table method,64 cases in each group.Both groups of patients were given conventional treatment,the control group was given Magnesium Sulfate combined with Nifedipine,and the observation group was given hyperbaric oxygen therapy on the basis of the control group.The efficacy,pregnancy outcome were compared between two groups,blood pressure[systolic blood pressure (SBP),diastolic blood pressure (DBP),mean arterial pressure (MAP)]and vascular endothelial function indexes[plasma endothelin (ET-1),von willebrand factor (vWF),nitric oxide (NO)]levels before and after treatment were compared between the two groups.Result:The total effective rate of the observation group was 89.06% higher than 75.00% of the control group,the difference was statistically significant (P<0.05).Before treatment,there were no significant differences in SBP,DBP,MAP,ET-1,NO,and vWF between the two groups (P>0.05);after treatment,the SBP,DBP,MAP,ET-1,and vWF of both groups were lower than those before treatment,NO of both groups were higher than those before treatment,and SBP,DBP,MAP,ET-1,vWF of the observation group were lower than those of the control group,and NO was higher than that of the control group,the differences were statistically significant (P<0.05).The natural delivery rate of the observation group was 71.88% higher than 42.19% of the control group,the difference was statistically significant (P<0.05).The incidence of adverse pregnancy outcomes of the observation group was 18.75% lower than 39.06% of the control group,the difference was st

关 键 词：妊娠期高血压疾病 高压氧 硝苯地平 硫酸镁 妊娠结局 血管内皮功能 

分 类 号：R714.246[医药卫生—妇产科学]