两种不同助孕方案在前次早卵泡期长方案助孕失败患者中的应用效果比较  

Comparison of the effect of two different pregnancy aid regimens in patients with previous pregnancy aid failure with long-term early follicular phase

作　　者：黄云 帅妹 岳林林 HUANG Yun;SHUAI Mei;YUE Lin-lin(Department of Reproductive and Genetics,Ganzhou Maternal and Child Health Hospital,Jiangxi Province,Ganzhou 341000,China)

机构地区：[1]江西省赣州市妇幼保健院生殖与遗传科,江西赣州341000

出　　处：《中国当代医药》2021年第26期144-147,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202140699)。

摘　　要：目的探究两种不同助孕方案在前次早卵泡期长方案助孕失败患者中的应用效果。方法选取2019年1月至2020年12月赣州市妇幼保健院收治的122例前次体外受精-胚胎移植助孕失败行再次助孕的患者作为研究对象,按照掷硬币法分为A组(52例)与B组(70例),A组采用早卵泡期长方案助孕方法,B组采用拮抗剂方案。比较两组的临床相关指标情况及促排结果。结果两组的获卵数、移植胚胎数比较,差异无统计学意义(P>0.05);B组的促性腺激素(Gn)总剂量少于A组,Gn天数短于A组,2原核胚胎数、卵裂数、可移植胚胎数多于A组,差异有统计学意义(P<0.05)。Gn启动日,两组卵泡刺激素(FSH)比较,差异无统计学意义(P>0.05),B组雌激素(E2)、促黄体生成素(LH)水平低于A组,差异有统计学意义(P<0.05);人绒毛膜促性腺激素(HCG)注射日,两组子宫内膜厚度比较,差异无统计学意义(P>0.05),B组的E2、孕酮水平高于A组,差异有统计学意义(P<0.05)。两组的优胚率、移植率、囊胚形成率、早期流产率比较,差异无统计学意义(P>0.05),B组的累积妊娠率高于A组,中重度卵巢过度刺激综合征(OHSS)发生率低于A组,差异有统计学意义(P<0.05)。结论对于早卵泡期长方案助孕失败者,再次助孕采用拮抗剂方案能够有效提高累积妊娠率,降低中重度OHSS发生率,效果显著。Objective To explore the application effect of two different pregnancy aid regimens in patients with previous pregnancy aid failure with long-term early follicular phase.Methods From January 2019 to December 2020,a total of 122 patients admitted to Ganzhou Maternal and Child Health Hospital,who had failed the previous in-vitro fertilization-embryo transfer assisted pregnancy and received the second assisted pregnancy were selected as the research subjects.According to the coin toss method,the patients were divided into group A(52 cases)and group B(70 cases).The patients in group A were treated with the long-term early follicular phase program,and the patients in group B were treated with the antagonist program.The clinical indicators and the results of ovulation induction were compared between the two groups.Results There was no statistical significance in the number of eggs obtained and the number of embryos transferred between the two groups(P>0.05).The total dose of gonadotropin(Gn)in group B was less than that in group A,and Gn days were shorter than that in group A.The number of 2 prokaryotic embryos,cleavage number and transferable embryos in group B were more than that in group A,the differences were statistically significant(P<0.05).On Gn initiation day,there was no statistical significance in FSH between two groups(P>0.05),the levels of estrogen(E2)and luteinizing hormone(LH)in group B were lower than those in group A,the differences were statistically significant(P<0.05).On the day of human chorionic gonadotropin(HCG)injection,there was no significant difference in endometrial thickness between the two groups(P>0.05),the levels of E2 and progesterone in group B were higher than those in group A,the differences were statistically significant(P<0.05).There was no statistical significance in the optimal embryo rate,transplantation rate,blastocyst formation rate and early abortion rate between the two groups(P>0.05).The cumulative pregnancy rate in group B was higher than that in group A,and the incidence o

关 键 词：助孕方案 前次早卵泡期 助孕失败 妊娠率 

分 类 号：R271.14[医药卫生—中医妇科学]