无痛人工流产术中予以丙泊酚复合芬太尼、舒芬太尼、瑞芬太尼的效果  

Efficacy of propofol combined with fentanyl,sufentanil and remifentanil in painless induced abortion

作　　者：于淼 YU Miao(Department of Anesthesiology,Affiliated Central Hospital of Shenyang Medical College,Shenyang 110024,China)

机构地区：[1]沈阳医学院附属中心医院麻醉科,辽宁沈阳110024

出　　处：《中国现代医生》2021年第22期140-143,共4页China Modern Doctor

摘　　要：目的探讨无痛人工流产术中予以丙泊酚复合芬太尼、舒芬太尼、瑞芬太尼的效果。方法选择2019年3月至2020年3月我院收治的78例无痛人工流产术患者进行分组研究,以随机数字表法分为三组,每组各26例,包括芬太尼组(丙泊酚复合芬太尼)、舒芬太尼组(丙泊酚复合舒芬太尼)、瑞芬太尼组(丙泊酚复合瑞芬太尼),比较三组丙泊酚用量、清醒时间、清醒时VAS评分、清醒1 h后VAS评分及不良反应发生率。结果瑞芬太尼组丙泊酚用量为(95.64±15.67)mg,明显低于芬太尼组的(119.04±12.64)mg与舒芬太尼组的(120.38±17.32)mg,差异有统计学意义(P<0.05),但三组患者清醒时间、清醒时VAS评分比较,差异无统计学意义(P>0.05),舒芬太尼组清醒1 h后VAS评分(4.01±1.24)分,明显低于芬太尼组的(5.20±0.85)分与瑞芬太尼组的(5.22±0.78)分,差异有统计学意义(P<0.05);三组患者低血压率、心动过缓率比较,差异无统计学意义(P>0.05);但瑞芬太尼组低氧血症率为26.92%,明显高于芬太尼组(7.69%)与舒芬太尼组(3.85%),差异有统计学意义(P<0.05)。结论无痛人工流产术中予以丙泊酚复合芬太尼、舒芬太尼、瑞芬太尼均有不错的效果,但舒芬太尼安全性好,镇痛效果较好。Objective To investigate the efficacy of propofol combined with fentanyl,sufentanil and remifentanil in painless induced abortion.Methods A total of 78 patients with painless induced abortion admitted to and treated in our hospital from March 2019 to March 2020 were selected for group research.They were divided into the fentanyl group(propofol combined with fentanyl,n=26),the sufentanil group(propofol combined with sufentanil,n=26)and the remifentanil group(propofol combined with remifentanil,n=26)according to the random number table method.The efficacies of the three groups were compared.The dosage of propofol,wakening time,VAS score during wakening,VAS score after 1 h wakening,and adverse reaction rate were compared among the three groups.Results The propofol dosage in the remifentanil group was(95.64±15.67)mg,which was significantly lower than(119.04±12.64)mg in the fentanyl group and(120.38±17.32)mg in the sufentanil group,with statistically significant differences(P<0.05).However,there were no statistically significant differences in awake time and VAS score during awake among the three groups of patients(P>0.05).The VAS score after 1 hour of awake in the sufentanil group was(4.01±1.24)points,which was significantly lower than(5.20±0.85)points in the fentanyl group and(5.22±0.78)points in the remifentanil group,with statistically significant differences(P<0.05).There were no statistically significant differences in the hypotension rate and bradycardia rate in the three groups of patients(P>0.05).However,the hypoxemia rate in the remifentanil group was 26.92%,which was significantly higher than 7.69% in the fentanyl group and 3.85% in the sufentanil group,with statistically significant differences(P<0.05).Conclusion Propofol combined with fentanyl,sufentanil and remifentanil has good efficacy in painless induced abortion,but sufentanil is safer and has better analgesic effect.

关 键 词：无痛人工流产术 丙泊酚 芬太尼 舒芬太尼 瑞芬太尼 

分 类 号：R614.3[医药卫生—麻醉学]