Th1样Th17细胞在自身免疫性疾病中的研究进展  

Research progress of Th1-like Th17 cells in autoimmune diseases

作　　者：崔雪雪 张智慧 陈爽 吴凌子 张晓敏(指导)[1] CUI Xue-Xue;ZHANG Zhi-Hui;CHEN Shuang;WU Ling-Zi;ZHANG Xiao-Min(Tianjin Medical University Eye Hospital,Tianjin Medical University Eye Institute,School of Optometry and Ophthalmology TMU,Tianjin 300384,China)

机构地区：[1]天津医科大学眼科医院,天津医科大学眼科研究所,天津医科大学眼视光学院,天津300384

出　　处：《中国免疫学杂志》2021年第17期2175-2176,F0003,F0004,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(81671642)。

摘　　要：辅助性T细胞17(Th17)具有高度可塑性,在一定炎症环境下可分化为主要表达γ干扰素(IFN-γ)的Th1样Th17细胞(CCR6+CXCR3+)。目前认为,这些Th1样Th17细胞是自身免疫性疾病的主要致病细胞。本文就Th1样Th17细胞的生物学特性、分化机制及其在自身免疫性疾病发展和发病机制中的作用进行综述,旨在为自身免疫性疾病治疗靶点提供新观点和建议。Th17 cells were highly malleable and can differentiate into Th1-like Th17 cells(CCR6+CXCR3+)which mainly expressed IFN-γunder a certain inflammatory environment.These Th1-like Th17 cells were presently believed to be causative agents of autoimmune diseases.In this article,biological characteristics and differentiation mechanism of Th1-like Th17 cells were described and their roles in development and pathogenesis of autoimmune diseases were reviewed,thereby providing new perspectives and suggestions of therapeutic targets for autoimmune diseases.

关 键 词：Th1样Th17细胞 自身免疫性疾病 Th17细胞可塑性 

分 类 号：R392[医药卫生—免疫学]