OX40/OX40L在免疫调节及相关疾病中的研究进展  

Research progress of OX40/OX40L in immune regulation and related diseases

作　　者：米执中 王勇 李莹莹(指导) MI Zhi-Zhong;WANG Yong;LI Ying-Ying(Basic Medical College of Dali University,Dali 671000,China)

机构地区：[1]大理大学基础医学院,大理671000

出　　处：《中国免疫学杂志》2021年第18期2282-2286,共5页Chinese Journal of Immunology

基　　金：国家自然基金(31960702);云南省应用基础研究计划项目(2017FH001-033)资助。

摘　　要：新型正性协同刺激分子OX40L为肿瘤坏死因子超家族成员,与其受体OX40的信号在免疫应答有效启动、适度效应和适时终止过程中起重要调节作用。近年研究证明,OX40/OX40L在相关疾病发生、发展中起重要作用。本文就OX40/OX40L的免疫调节特性及其在炎症性疾病、肿瘤及自身免疫性疾病中的研究进展进行综述。OX40L was an important new positive co-stimulatory molecule belonging to tumor necrosis factor superfamily,whose signals with its receptor OX40 played a crucial regulatory role in effective initiation,moderate effect and timely termination of immune responses regulating.In recent years,a large number of studies proved that OX40L signals were particularly important for occurrence and development of related diseases.This article reviewed research progress of OX40/OX40L in its immune regulation function,inflammatory diseases,oncology diseases and autoimmune diseases.

关 键 词：OX40/OX40L 免疫调节 炎症性疾病 肿瘤性疾病 自身免疫病 

分 类 号：R392[医药卫生—免疫学]