间充质干细胞外泌体在眼部疾病中的研究进展  

Research progress of mesenchymal stem cell exosomes in ocular diseases

作　　者：付长秀 孙建伟[2] 张芸 吴文哲 郑永钦[2] 贺军栋(指导) FU Chang-Xiu;SUN Jian-Wei;ZHANG Yun;WU Wen-Zhe;ZHENG Yong-Qin;HE Jun-Dong(School of Medicine,Kunming University of Science and Technology,Kunming 650000,China)

机构地区：[1]昆明理工大学医学院,昆明650000 [2]云南省第一人民医院,昆明650034

出　　处：《中国免疫学杂志》2021年第18期2295-2299,共5页Chinese Journal of Immunology

基　　金：云南省中青年学术和技术带头人后备人才(2018HB050);云南省万人计划青年拔尖人才(YNWR-QNBJ-2018-070)资助。

摘　　要：眼部疾病病因复杂且种类多种多样,主要包括眼眶、角膜、虹膜、视神经、视网膜等疾病,如果不及时治疗或处理不当会导致视力模糊,严重的会导致失明。手术和药物治疗存在一定的局限性。近几年,由于间充质干细胞(MSC)具有免疫调节和促进血管生成等特性,在许多眼部疾病的细胞疗法中被广泛探索。随着无细胞疗法的兴起,间充质干细胞外泌体(MSC-Exos)的深入研究为眼部疾病的治疗注入了新的活力。本文就间充质干细胞外泌体治疗眼部疾病的相关研究进展进行综述。The causes of eye diseases are complex and varied,mainly including diseases of the orbit,cornea,iris,optic nerve,and retina.If these diseases are not treated in time or improperly treated,it will lead to blurred vision and severe blindness.Surgery and medicine have certain limitations.In recent years,mesenchymal stem cells have been widely explored in cell therapy for many eye diseases due to their immunomodulatory and angiogenic properties.With the rise of cell-free therapy,the in-depth study of mesenchymal stem cell exosomes has injected new vitality into the treatment of eye diseases.This article reviews the research progress of exosomes in treating eye diseases.

关 键 词：间充质干细胞外泌体 角膜 视网膜 神经 

分 类 号：R322.91[医药卫生—人体解剖和组织胚胎学]