Kinetics Study on Reaction of Atenolol with Singlet Oxygen by Directly Monitoring the^(1)O_(2)Phosphorescence  

作　　者：Chen Wang Ming-chen Xiong Xuan Zhao Kun-hui Liu 

机构地区：[1]College of Chemistry,Beijing Normal University,Beijing 100875,China

出　　处：《Chinese Journal of Chemical Physics》2021年第4期406-412,I0002,共8页化学物理学报（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(No.21773013).

摘　　要：The pharmaceuti-cally active com-pound atenolol,a kind of β-blockers,may result in ad-verse effects both for human health and ecosystems if it is excreted to the surface water resources.To e ectively remove atenolol in the environ-ment,both direct and indirect photodegradation,driven by sunlight play an important role.Among indirect photodegradation,singlet oxygen(^(1)O_(2)),as a pivotal reactive species,is likely to determine the fates of atenolol.Nevertheless,the kinetic information on the re-action of atenolol with singlet oxygen has not been well investigated and the reaction rate constant is still ambiguous.Herein,the reaction rate constant of atenolol with singlet oxy-gen is investigated directly through observing the decay of the^(1)O_(2)phosphorescence at 1270 nm.It is determined that the reaction rate constant between atenolol and^(1)O_(2)is 7.0×10^(5)(mol/L)^(-1)·s^(-1)in D2O,8.0×10^(6)(mol/L)^(-1)·s^(-1)in acetonitrile,and 8.4×10^(5)(mol/L)^(-1)·s^(-1)in EtOH,respectively.Furthermore,the solvent effects on the title reaction were also inves-tigated.It is revealed that the solvents with strong polarity and weak hydrogen donating ability are suitable to achieve high rate constant values.These kinetics information on the reaction of atenolol with singlet oxygen may provide fundamental knowledge to the indirect photodegradation of β-blockers.

关 键 词：ATENOLOL Rate constant Singlet oxygen Time resolved spectroscopy 

分 类 号：O657.3[理学—分析化学] X703[理学—化学]