自身免疫性卵巢早衰患者性激素水平与T淋巴细胞的相关性分析  

Correlation Analysis of Sex Hormone Levels and T-lymphocyte in Patients with Autoimmune O-varian Failure

作　　者：李丽丽 马锦 LI Li-li;MA Jin(Department of Gynecology,Weinan Central Hospital,Weinan 714000)

机构地区：[1]陕西省渭南市中心医院妇科,陕西渭南714000 [2]蓝田县人民医院检验科,陕西蓝田710500

出　　处：《医学临床研究》2021年第8期1204-1207,共4页Journal of Clinical Research

摘　　要：【目的】探讨自身免疫性卵巢早衰(POF)患者性激素水平与T淋巴细胞的相关性。【方法】选择陕西省渭南市中心医院2017年1月至2020年1月收治的80例自身免疫性POF患者作为观察组,另外选取同期同院80名健康女性志愿者作为对照组。检测两组雌二醇(E_(2))、黄体生成素(LH)、促卵泡生成素(FSH)、T淋巴细胞[分化簇3阳性(CD3^(+))、分化簇4阳性(CD4^(+))、分化簇8阳性(CD8^(+))],并计算CD4^(+)/CD8^(+);分析自身免疫性POF患者性激素水平与T淋巴细胞的相关性。【结果】与对照组相比,观察组E_(2)水平较低,LH、FSH水平较高,其差异有统计学意义(P<0.05)。与对照组相比,观察组CD4^(+)T淋巴细胞百分比、CD4^(+)/CD8^(+)值较低,CD8^(+)T淋巴细胞百分比较高,其差异有统计学意义(P<0.05);但两组CD3^(+)T淋巴细胞百分比比较差异无统计学意义(P>0.05)。相关性分析结果显示:自身免疫性POF患者E:水平与CD4^(+)T淋巴细胞百分比、CD4^(+)/CD8^(+)值呈正相关(P<0.05),与CD8^(+)T淋巴细胞百分比呈负相关(P<0.05);LH、FSH水平与CD4^(+)T淋巴细胞百分比、CD4^(+)/CD8^(+)值呈负相关(P<0.05),与CD8^(+)T淋巴细胞百分比呈正相关(P<0.05);E_(2)、LH、FSH水平与CD3^(+)T淋巴细胞百分比无明显相关性(P>0.05)。【结论】与正常女性相比,自身免疫性POF患者存在阴显的性激素水平失调和免疫功能紊乱,且性激素水平与T淋巴细胞呈明显相关。【Objective】To investigate the correlation between sex hormone levels and T lymphocytes in patients with autoimmune premature ovarian failure(POF).【Methods】A total of 80 patients with autoimmune POF in our hospital from January 2017 to January 2020 were selected as the observation group,and 80 healthy women were selected as the control group.Levels of estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH),T lymphocytes[Cluster of differentiation 3 positive(CD3^(+)),Cluster of differentiation 4 positive(CD4^(+)),Cluster of differentiation 8 positive(CD8^(+))],and CD4^(+)/CD8^(+)was were measured and calculated.The correlation between the levels of sex hormones and T-lymphocytes in patients with autoimmune POF was analyzed by Spearman coefficient.【Results】Compared to the control group,the observation group had lower E_(2)level,higher LH and FSH levels;and the difference was statistically significant(P<0.05).Compared to the control group the observation group showed lower percentage of CD4^(+)T cells and CD4^(+)/CD8^(+)ratio,while the level of CD8^(+)T cells was higher.The differences were statistically significant(P<0.05).There was no significant difference in the levels of CD3^(+)T cells between the two-groups(P>0.05).According to correlation analysis,Eg level in patients with autoimmune POF was positively correlated with CD4^(+)T cells percentage and CD4^(+)/CD8^(+)ratio,while,negatively correlated with CD8^(+)T cell percentage.The differences were statistically significant(P<0.05).LH and FSH levels were negatively correlated with CD4^(+)T cells,CD4^(+)/CD8^(+)ratio,and positively correlated with CD8^(+)T cells levels.The differences were statistically significant(P<0.05).There were no obvious correlation between CD3^(+)T cell percentage and levels of E,LH and FSH(P>0.05).【Conclusion】ompared with normal women,patients with autoimmune premna-ture ovarian failure have obvious disorder of sex hormone levels and immune function.Ep level is positively correlatedwith CD4^(+)T cells and C

关 键 词：原发性卵巢功能不全 自身免疫疾病 性腺甾类激素 T淋巴细胞 

分 类 号：R711.51[医药卫生—妇产科学]