氟啶虫酰胺类衍生物的合成与生物活性测试  

Synthesis and Biological Activity Test of Fluoridintranamide Derivative

作　　者：胡荣月 谢锐 陈驰[1] 潘勇 陈坤[1] 徐保明[1] HU Rong-yue;XIE Rui;CHEN Chi;PAN Yong;CHEN Kun;XU Bao-ming(Hubei Province Graduate Workstation,Hubei University ofTechnology,Wuhan 430068,China)

机构地区：[1]湖北工业大学湖北省研究生工作站,武汉430068

出　　处：《农药》2021年第9期638-641,共4页Agrochemicals

基　　金：科技部中小企业创业基金项目(12C26214204453);湖北省自然科学基金计划青年项目(2018CFB359)。

摘　　要：[目的]合成氟啶虫酰胺类衍生物,探究合成方法,并测试杀虫、杀菌活性。[方法]以中间体2,6-二氯-3-氰基-4-三氟甲基吡啶为起始原料,经3步反应合成氟啶虫酰胺类衍生物。并对其进行了红外,元素分析,1H NMR,MS结构表征和杀虫活性测试。[结果]以2,6-二氯-3-氰基-4-三氟甲基吡啶计总收率大于66%,合成的氟啶虫酰胺类衍生物在25~100 mg/L质量浓度下对小菜蛾和棉铃虫都有一定的杀虫活性。[结论]为氟啶虫酰胺类衍生物的设计与合成提供新的思路。[Aims] This study aims to synthesize fluridinamide derivatives, explore synthetic methods, and to test the insecticidal and bactericidal activities. [Methods] It was prepared by using 2,6-dichloro-3-cyano-4-trifluoromethylpyridine as the starting material through a three-step reaction. The structure was characterized by IR, elemental analysis,1 H NMR, MS, and its insecticidal activity was tested. [Results] Based on 2,6-dichloro-3-cyano-4-trifluoromethylpyridine,the total yield is more than 66%. The results of biological activity showed that the as-synthesized fluoridetanyamidine derivative had certain insecticidal activity against diamondback moth and cotton bollworm at 25-100 mg/L.[Conclusions] It provides a new idea for the design and synthesis of fluoridetanyamidine derivative.

关 键 词：氟啶虫酰胺 氟啶虫酰胺类衍生物 合成 杀虫活性 

分 类 号：TQ460.3[化学工程—制药化工]