少腹逐瘀汤灌肠联合肾俞穴位埋线治疗复发性子宫内膜异位症30例  

Shaofu Zhuyu decoction enema combined with Shenshu acupoint catgut embedding in treating 30 cases of recurrent endometriosis

作　　者：余琳[1] 张萍 全晓广[1] Yu Lin;Zhang Ping;Quan Xiaoguang

机构地区：[1]佛山市南海区妇幼保健院,广东佛山528200

出　　处：《中医临床研究》2021年第15期119-122,共4页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨少腹逐瘀汤灌肠联合肾俞穴位埋线治疗复发性子宫内膜异位症的临床疗效。方法:将2018年1月-2020年1月佛山市南海区妇幼保健院门诊就诊的复发性子宫内膜异位症患者60例随机分为两组,每组各30例,观察组采用少腹逐瘀汤煎剂保留灌肠及肾俞穴位埋线,对照组口服屈螺酮炔雌醇(II)活性片,两组疗程均为3个月。观察两组患者治疗前后疼痛评分、CA125水平、囊肿最大径线的变化。比较两组治疗前后血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)、白细胞介素6(Interleukin-6,IL-6)、白细胞介素8(Interleukin-8,IL-8)及肿瘤坏死因子(Tumor Necrosis Factor-α,TNF-α)水平的变化情况。比较两组治疗前后CD4、CD8、NK细胞百分比及CD4/CD8比值。对比两组治疗后复发率及不良反应情况。结果:两组患者治疗后疼痛评分、CA125水平、囊肿最大径线均较治疗前明显下降(P <0.05),两组治疗后的疼痛评分、CA125水平差异无统计学意义(P> 0.05),观察组治疗后内膜异位囊肿最大径线及复发率小于对照组(P <0.05)。两组治疗3个月后VEGF、IL-6、IL-8、TNF-α水平较本组治疗前明显下降(P <0.05),观察组治疗后各细胞因子水平均低于对照组(P <0.05)。观察组治疗3个月后CD4、CD8、CD4/CD8比值较治疗前明显降低(P <0.05),NK细胞百分比较治疗前升高。对照组治疗前后CD4、CD8、CD4/CD8、NK细胞对比差异无统计学意义(P> 0.05)。观察组不良反应率较对照组小(P <0.05)。结论:少腹逐瘀汤灌肠联合肾俞穴位埋线治疗复发性子宫内膜异位症是安全、有效的。Objective: To discuss the efficacy of Shaofu Zhuyu decoction(少腹逐瘀汤)enema combined with Shenshu(肾俞)acupoint catgut embedding in the treatment of recurrent endometriosis. Methods: 60 recurrent endometriosis patients treated from January 2018 to January 2020 in the department of gynecology of Maternity and Children’s Healthcare of Nanhai District were selected. The subjects were randomly assigned to the control group(30 cases) and the observation group(30 cases). Patients of the observation group received Shaofu Zhuyu decoction enema combined with Shenshu acupoint catgut embedding. Patients of the control group received drospirenone and ethinylestradiol(II) tablets. After 3 months of treatment, pain score, CA125 level, maximum diameter of recurrent endometriosis cyst were compared. The levels of VEGF, IL-6, IL-8 and TNF-α,the percentage of CD4, CD8, NK cells and the ratio of CD4/CD8 were compared between the two groups. The recurrence rate and adverse reactions were compared between the two groups. Results: The pain score,CA125 level and the maximum diameter of cysts in the two groups were significantly lower than those before treatment(P<0.05). There was no significant difference in pain score and CA125 level between the two groups after treatment(P>0.05). The maximum diameter of endometriosis cyst in the observation group was smaller and the recurrence rate in the observation group was lower than that in the control group after treatment(P<0.05). Compared with those before treatment, VEGF, IL-6, IL-8, TNF-α levels in the two groups decreased significantly after 3 months of treatment(P<0.05), and the levels of cytokines in the observation group were lower than those in the control group(P<0.05). After 3 months of treatment, CD4,CD8, CD4/CD8 ratio in the observation group were significantly lower than those before treatment(P<0.05), NK cells percentage was higher than that before treatment. There was no significant difference in CD4, CD8, CD4/CD8, NK cells before and after treatment in the control

关 键 词：少腹逐瘀汤 保留灌肠 肾俞 穴位埋线 复发性子宫内膜异位症 屈螺酮炔雌醇(Ⅱ)片 

分 类 号：R711.71[医药卫生—妇产科学]