基于数据挖掘的孙一奎《赤水玄珠》妇科病证用药规律  

Medication laws of gynecological diseases in Sun Yikui’s Chishui Xuanzhu based on data mining

作　　者：王钰 翁家俊 赵永红[2] 杨宜花[1] Wang Yu

机构地区：[1]江西中医药大学科技学院,江西南昌330004 [2]江西中医药大学人文学院,江西南昌330004

出　　处：《中医临床研究》2021年第16期20-23,共4页Clinical Journal Of Chinese Medicine

基　　金：2020年度省级大学生创新创业训练计划(S202013437001);江西省教育改革项目(JXJG-16-40-2);江西中医药大学校级教改项目(2017jzyb-10)。

摘　　要：目的:对《赤水玄珠》中关于孙一奎诊治妇科病证的方药进行数据分析,探讨孙一奎治疗妇科疾病用药规律和治疗特色。方法:采用Microsoft Office Excel 2010建立数据库,采用IBM SPSS Modeler 18.0及IBM SPSS Statistics 22.0软件对药物使用频数、性味、归经、功效等进行数据分析。结果:根据纳入及排除标准最终得到方剂共453首,包含257味药,用药频数共计3 166次。结果显示,药物使用频率较高的前三项依次为甘草、当归、人参;性味及功效以甘温之补虚药、苦寒之清热药为主,主归脾肺肝经;药物关联规则核心组合为四君子汤结构"人参-白术-白茯苓-甘草";聚类分析共得到5类组合,包括"牡丹皮-栀子-柴胡-生地黄-黄芩-半夏-生姜-陈皮""白术-白茯苓-人参-黄芪""川芎-熟地黄-肉桂-白芍药""当归""甘草"。结论:孙一奎诊治妇科病证立足妇人之本,尤重保护脾胃,和肝达肺,顺气和血;用药首重明证,不滥苦寒,不畏甘温,不拘一法;组方善用四君子汤、四物汤为基础,辅以疏肝清热,燥湿化痰。这对于妇科疾病的研究与临床治疗具有积极的参考价值。Objective: According to analyzing the data of Sun Yikui’s prescriptions for gynecological diseases in Chishui Xuanzhu(《赤水玄珠》), Sun Yikui’s medication rules and treatment characteristics for treating gynecological diseases was explored. Methods: Microsoft Office Excel 2010 was used to establish the database, and IBM SPSS Modeler 18.0 and IBM SPSS Statistics 22.0 software were used to analyze the data of medication frequency, property and flavor, channel tropism, efficacy and so on. Results: According to the inclusion and exclusion criteria, 453 prescriptions were finally obtained, including 257 medicinals, with a total of 3 166 times of medication frequency. The results showed that the top three medicines with higher frequency were Gancao(Glycyrrhiza uralensis Fisch), Danggui [Angelica sinensis(Oliv.) Diels] and Renshen(Panax ginseng C. A. Meyer). In terms of property and flavor, and efficacy, the medicinals that tonifying deficiency with sweet and warm nature and the medicinals that clearing heat with bitter and cold nature played major roles, which are mainly indicated for spleen meridian, liver meridian and lung meridian. The core combination rule of medicinals is “Renshen-Baizhu-Baifuling-Gancao”(人参-白术-白茯苓-甘草). Five kinds of combinations were obtained by cluster analysis, including “Mudanpi-Zhizi-Chaihu-Shengdihuang-Huangqin-Banxia-Shengjiang-Chenpi”(牡丹皮-栀子-柴胡-生地黄-黄芩-半夏-生姜-陈皮), “Baizhu-Baifuling-Renshen-Huangqi”(白术-白茯苓-人参-黄芪), “Chuanxiong-Shudihuang-Rougui-Baishao”(川芎-熟地黄-肉桂-白芍药), “Danggui”, and “Gancao”. Conclusion: Sun Yikui’s diagnosis and treatment approach for gynecological diseases is based on women, especially focuses on protection of spleen and stomach, dispersing stagnated Qi(气) in the liver and the lung, bringing down adverse flow of Qi as well as harmonizing blood. The most attention of the Sun Yikui is paid to syndrome differentiation and treatment. The Sijunzi dec

关 键 词：《赤水玄珠》 妇科病证 用药规律 

分 类 号：R289[医药卫生—方剂学]