苦苣菜药材细粉混悬液安全药理学研究  

Safety Pharmacology Study of Sonchus Oleraceus Powder Suspension

作　　者：李君[1,2] 常福厚[1,2,3] 白图雅 胡玉霞[1,2] 王敏杰 张梦迪[1,2,5] LI Jun;CHANG Fuhou;BAI Tuya;HU Yuxia;WANG Minjie;ZHANG Mengdi(Inner Mongolia Medical University,The Center for New Drug Safety Evaluation and Research,College of Pharmacy,Hohhot 010110,China;Inner Mongolia Medical University,Research Center for Drug Screening,College of Pharmacy,Hohhot 010110,China;Inner Mongolia Medical University,Department of Pharmacology,College of Pharmacy,College of Pharmacy,Hohhot 010110,China;Inner Mongolia Medical University,Department of Pharmacology,Basic Medical College,College of Pharmacy,Hohhot 010110,China;Inner Mongolia Medical University,Pharmacy Experimental Teaching Center,College of Pharmacy,Hohhot 010110,China)

机构地区：[1]内蒙古医科大学新药安全评价研究中心,呼和浩特010110 [2]内蒙古医科大学新药筛选工程研究中心,呼和浩特010110 [3]内蒙古医科大学药学院药理教研室,呼和浩特010110 [4]内蒙古医科大学基础医学院药理教研室,呼和浩特010110 [5]内蒙古医科大学药学实验教学中心,呼和浩特010110

出　　处：《中国现代应用药学》2021年第15期1813-1819,共7页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目(81760676);内蒙古自治区自然科学基金项目(2019LH08017);内蒙古医科大学青年创新基金项目(YKD2018QNCX023)。

摘　　要：目的观察苦苣菜细粉混悬液对实验动物中枢神经系统和心血管系统的影响,为进一步临床研究和安全用药提供依据。方法ICR小鼠单次灌胃给予0.13,0.39,1.17 g·kg^(−1)苦苣菜细粉混悬液,SD大鼠单次灌胃给予0.09,0.27,0.81 g·kg^(−1)苦苣菜细粉混悬液,通过小鼠自主活动试验、协调催眠试验和大鼠转棒试验,考察苦苣菜细粉混悬液对中枢神经系统的影响。Beagle犬单次灌胃给予0.03,0.09,0.27 g·kg^(−1)苦苣菜细粉混悬液,通过检测清醒Beagle犬心电、血压和体温,考察苦苣菜细粉混悬液对心血管系统和体温的影响。结果苦苣菜细粉混悬液对实验动物自主活动行为、协调功能和戊巴比妥钠阈下睡眠剂量小鼠入睡率无明显影响;对Beagle比格犬的心电、血压、体温均无明显影响。结论本实验条件下,单次灌胃给予苦苣菜细粉混悬液对Beagle犬心血管系统和ICR小鼠、SD大鼠中枢神经系统无明显影响。OBJECTIVE To observe the effects of Sonchus oleraceus powder suspension on the central nervous system and cardiovascular system of experimental animals so as to provide evidence for further clinical study and safty medication.METHODS ICR mice were given a single dose of Sonchus oleraceus powder suspension of 0.13,0.39 and 1.17 g⋅kg^(−1) and SD rats were given a single dose of Sonchus oleraceus powder suspension of 0.09,0.27 and 0.81 g⋅kg^(−1) by oral administration,the effects of Sonchus oleraceus powder suspension on the central nervous system were observed by mice autonomic activity experiment,coordinating hypnosis test and rat rotating rod experiment.Beagle dogs were given a single dose of Sonchus oleraceus powder suspension of 0.03,0.09 and 0.27 g⋅kg^(−1) by oral administration,the effects of Sonchus oleraceus powder suspension on cardiovascular system and body temperature were observed by measuring electrocardiogram,blood pressure and body temperature in sober Beagle dogs.RESULTS There were no significant in fluence of Sonchus oleraceus powder suspension on autonomic activity,coordinated movements and sleep rate of mice with the sub-threshold sleep dose of pentobarbital sodium.Similarly,there were no significant effects on electrocardiogram,blood pressure and body temperature of Beagle dogs.CONCLUSION Single intragastric administration of Sonchus oleraceus powder suspension has no significant effects on the cardiovascular system of Beagle dogs and the central nervous system of ICR mice and SD rats under the condition.

关 键 词：苦苣菜 安全药理学 遥测 心血管系统 中枢神经系统 

分 类 号：R285.5[医药卫生—中药学]