载银磷酸钙的缓释性研究及抗菌性能评价  

Sustained Release Performance and Antibacterial Properties of Silver-doped Calcium Phosphate

作　　者：周锡荣 黄玲艳 曾为民 李嘉胤 黄剑锋[3] ZHOU Xirong;HUANG Lingyan;ZENG Weimin;LI Jiayin;HUANG Jianfeng(Monalisa Group Co.,Ltd.,Foshan 528211,Guangdong,China;China Light Industry Key Laboratory of Inorganic Materials,Foshan 528211,Guangdong,China;School of Materials Science and Engineering,Shaanxi Science&Technology University,Xi’an 710021,Shaanxi,China)

机构地区：[1]蒙娜丽莎集团股份有限公司,广东佛山528211 [2]中国轻工业无机材料重点实验室,广东佛山528211 [3]陕西科技大学材料科学与工程学院,陕西西安710021

出　　处：《陶瓷学报》2021年第4期626-631,共6页Journal of Ceramics

基　　金：国家博士后基金特别资助项目(2018T110879)。

摘　　要：磷酸钙是一种耐高温、生物相容性好的无机抗菌载体。以Ca(OH)_(2)、H_(3)PO_(4)、AgNO_(3)为反应原料,NH_(3)·H_(2)O调节反应体系pH值,采用一步湿法合成了载银磷酸钙粉体。XRD和EDS表征显示,控制Ca/P摩尔比为1.5、pH值为7.4,合成的磷酸钙粉体,其主晶相为磷酸三钙(β-TCP)。研究表明,载银磷酸钙粉体的缓释性与制备条件、载银量、使用环境有关。以大肠杆菌、白色葡萄球菌、枯草芽孢杆菌作为抗菌目标,抗菌结果显示,载银量为3.30 wt.%的磷酸钙粉体对它们均具有很好的抗菌性能,抑菌圈的平均宽径比为0.317。Calcium phosphate is an excellent inorganic antibacterial carrier,with high temperature resistance and good biocompatibility.Silver-doped calcium phosphate powder was synthesized by using a one-step wet mothed,with Ca(OH)_(2),H_(3)PO_(4) and AgNO_(3) as the raw materials and NH_(3)·H_(2)O to adjust pH value of reaction system.XRD and EDS results indicated that the main crystal phase was tricalcium phosphate(β-TCP),as the Ca/P molar ratio was 1.5,pH value was 7.4.It was found that the release performance of the silver-doped calcium phosphate was strongly dependent on the preparation conditions,the mass of fraction of silver and application environment.The calcium phosphate powder with 3.30 wt.%silver had good antibacterial performance for Escherichia coli,Staphylococcus albus and Bacillus subtilis them,with the average width-diameter ratios of bacteriostatic zone to be 0.317.

关 键 词：磷酸钙 缓释 抗菌材料 抗菌性能 

分 类 号：TQ174.75[化学工程—陶瓷工业]