ZTC1+1澄清剂在清咽复方水提液澄清工艺中的应用  

Application of ZTC1+1 Clarifier in Water Extract of Qingyan Compound

作　　者：楚婷花 田密 麻开香 李英 CHU Ting-hua;TIAN Mi;MA Kai-xiang(Shanxi Zhendong Wuhe Health Technology Co.,Ltd.,Changzhi,Shanxi 046000;Shanxi Zhendong Pharmaceutical Co.,Ltd.,Changzhi,Shanxi 046000)

机构地区：[1]山西振东五和健康科技股份有限公司,山西长治046000 [2]山西振东制药股份有限公司,山西长治046000

出　　处：《安徽农业科学》2021年第18期172-176,共5页Journal of Anhui Agricultural Sciences

摘　　要：[目的]研究清咽复方水提液的澄清工艺。[方法]先通过单因素试验研究澄清剂用量、药液浓度(生药量∶药液量)、絮凝温度分别对出膏率、绿原酸和总皂苷含量的影响,再通过正交试验优化最佳工艺条件。[结果]澄清剂用量对综合指标的影响最大,药液浓度次之。最佳澄清工艺:在药液浓度(生药量∶药液量)为1∶6(g∶mL)时,加入8%B组分和4%A组分,水浴温度80℃。在此工艺条件下,出膏率为19.13%,绿原酸含量为592.81 mg/g,总皂苷含量为473.15 mg/g。[结论]ZTC1+1天然澄清剂对清咽复方水提液的澄清效果良好,且工艺稳定可行。[Objective]To study the optimal clarification technology of water extract of Qingyan compound.[Method]Single factor experiment design was used to research the effect of dosage of ZTC1+1,drug liquid concentration and reaction temperature on extract rate,content of chlorogenic acid and total saponins.The optimal clarification process was determined by orthogonal experiment design.[Result]Comprehensive index was mainly influenced by dosage of ZTC1+1,the following being drug liquid concentration.The optimal clarification process was as follows:the concentration of drug liquid(quality of material:quality of drug liquid)was 1∶6(g∶mL),the amount of clarifier was 8%component B and 4%component A,the reaction temperature was at 80℃.Under these conditions,the drug liquid concentration was 19.13%,the content of chlorogenic acid and total saponins was 592.81 mg/g and 473.15 mg/g,respectively.[Conclusion]ZTC1+1 natural clarifier has good effect on the clarification of water extract of Qingyan compound with promising feasibility and stability.

关 键 词：清咽复方水提液 ZTC1+1天然澄清剂 澄清工艺 应用 

分 类 号：TQ461[化学工程—制药化工]