氯吡格雷联合阿司匹林肠溶片在急性心肌梗死治疗中的效果分析  

Effect analysis of clopidogrel combined with aspirin enteric-coated tablets in the treatment of acute myocardial infarction

作　　者：潘朦朦 杨东妮[1] 刘欣卉 PAN Meng-meng;YANG Dong-ni;LIU Xin-hui(Department of Cardiology,Shenyang Red Cross Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市红十字会医院心内科,110000 [2]辽宁中医药大学,110000

出　　处：《中国现代药物应用》2021年第17期155-158,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨氯吡格雷联合阿司匹林肠溶片治疗急性心肌梗死(AMI)的效果。方法94例AMI患者,按照编号单双数分为对照组(奇数)和观察组(偶数),每组47例。对照组采用阿司匹林肠溶片治疗,观察组在对照组基础上联合氯吡格雷治疗。比较两组临床疗效、冠状动脉(冠脉)再通情况、凝血指标、不良事件发生情况。结果观察组患者治疗总有效率为95.74%,高于对照组80.85%,差异具有统计学意义(P<0.05)。两组患者再通率比较差异无统计学意义(P>0.05);观察组患者再闭塞率2.13%(1/47)、血小板聚集率(PAR)(36.34±6.28)%低于对照组的12.77%(6/47)、(47.05±6.12)%,再通时间(40.17±1.45)min短于对照组的(44.32±1.18)min,左室射血分数(LVEF)(52.06±6.62)%高于对照组的(42.78±5.99)%,差异具有统计学意义(P<0.05)。治疗前,两组患者凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fg)比较差异无统计学意义(P>0.05);治疗后,观察组PT、APTT长于对照组,Fg水平低于对照组,差异具有统计学意义(P<0.05)。两组患者不良事件发生率比较差异无统计学意义(P>0.05)。结论采用氯吡格雷联合阿司匹林肠溶片治疗AMI,能够明显改善患者乏力、胸前疼痛、心悸等临床病症,促进心脏功能逐渐恢复正常。Objective To discuss the effect analysis of clopidogrel combined with aspirin entericcoated tablets in the treatment of acute myocardial infarction(AMI).Methods A total of 94 AMI patients were divided into control group(odd number)and observation group(even number)according to the odd and even numbers,with 47 cases in each group.The control group was treated with aspirin enteric-coated tablets,and the observation group was treated with clopidogrel on the basis of control group.The clinical efficacy,coronary artery recanalization,coagulation indexes,and occurrence of adverse events were compared between the two groups.Results The total effective rate in the observation group was 95.74%,which was higher than 80.85%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the recanalization rate between the two groups(P>0.05).The re-occlusion rate 2.13%(1/47),platelet aggregation rate(PAR)(36.34±6.28)%of the observation group were lower than 12.77%(6/47)and(47.05±6.12)%of the control group,recanalization time(40.17±1.45)min was shorter than(44.32±1.18)min of the control group,and the left ventricular ejection fraction(LVEF)(52.06±6.62)%was higher than(42.78±5.99)%of the control group.All the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in prothrombin time(PT),activated partial thromboplastin time(APTT),and fibrinogen(Fg)between the two groups(P>0.05).After treatment,the PT and APTT of the observation group were longer than those of the control group,and the Fg level was lower than that of the control group.All the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse events between the two groups(P>0.05).Conclusion Combination of clopidogrel and aspirin enteric-coated tablets can significantly improve the clinical symptoms of fatigue,chest pain,palpitation,and promote the gradual recovery of cardi

关 键 词：急性心肌梗死 氯吡格雷 阿司匹林肠溶片 凝血指标 冠脉再通情况 不良事件 

分 类 号：R542.22[医药卫生—心血管疾病]