甘露饮加减对早期糖尿病肾病阴虚湿热型的疗效分析  

Analysis of Curative Effect of Ganluyin on Early Diabetic Nephropathy of Yin-deficiency and Damp-heat Type

作　　者：刘颖 徐丹 张晓春 肖扬 王润韵 LIU Ying;XU Dan;ZHANG Xiaochun;XIAO Yang;WANG Runyun(Department of Nephrology,Qiqihar Hospital of Traditional Chinese Medicine,Qiqihar,Heilongjiang Province,161000 China)

机构地区：[1]齐齐哈尔市中医医院肾病科,黑龙江齐齐哈尔161000

出　　处：《糖尿病新世界》2021年第13期40-43,共4页Diabetes New World Magazine

基　　金：齐齐哈尔市科技攻关项目(CSFGG-2020023)。

摘　　要：目的对早期糖尿病肾病阴虚湿热型患者,采用甘露饮加减治疗,观察其临床治疗效果。方法选择2020年1—12月来该院进行治疗的60例早期糖尿病肾病阴虚湿热型患者作为研究对象,分为观察组与对照组,对所有患者进行血糖控制治疗,合理饮食指导,对蛋白质的摄入量进行控制,在此基础上给予对照组患者盐酸贝那普利片进行治疗,观察组患者在对照组治疗基础上采用甘露饮加减治疗。经过3个月的治疗后,采用全自动生化分析仪测定两组患者的尿微量白蛋白排泄率(UAER)、肌酐(Scr)、尿素氮(BUN)、糖化血红蛋白(HbA1c),比较两组患者的临床治疗效果和不良反应发生情况。结果治疗结束后,观察组患者临床治疗有效率为86.67%,明显高于对照组50.00%,差异有统计学意义(χ^(2)=7.702,P<0.05)。从UAER、SCr、BUN、HbA1c等各项临床指标情况来看,观察组均要明显优于对照组,差异有统计学意义(P<0.05)。从空腹血糖水平及餐后2 h血糖水平来看,观察组分别为(5.38±1.78)、(7.42±1.59)mmol/L,优于对照组,差异有统计学意义(P<0.05)。从不良反应情况来看,观察组患者的不良反应发生率为6.67%,明显低于对照组的20.00%,但是两组差异无统计学意义(χ^(2)=1.298,P>0.05)。结论采用甘露饮加减治疗早期糖尿病肾病阴虚湿热型患者,能够有效降低患者血糖水平,降低UAER,改善各项临床数据指标,提高临床治疗效果。Objective To treat patients with Yin-deficiency and damp-heat type in early diabetic nephropathy,use Ganluyin plus or minus treatment to observe its clinical therapeutic effect.Methods From January to December 2020,60 cases of early diabetic nephropathy patients with yin deficiency and damp-heat type who came to the hospital for treatment were selected as the research objects.They were divided into observation group and control group,and all patients were treated with blood glucose control.Reasonable dietary guidance and control of protein intake.On this basis,patients in the control group were given benazepril hydrochloride tablets for treatment,and patients in the observation group were treated with Ganluyin addition and subtraction on the basis of the treatment of the control group.After 3 months of treatment,the urinary microalbumin excretion rate(UAER),creatinine(Scr),urea nitrogen(BUN),and glycosylated hemoglobin(HbA1c)of the two groups of patients were measured with an automatic biochemical analyzer to compare the two groups of patients of the clinical treatment effect and the occurrence of adverse reactions.Results After the treatment,the clinical treatment effective rate of the observation group was 86.67%,which was significantly higher than that of the control group 50.00%,the difference was statistically significant(χ^(2)=7.702,P<0.05).From the clinical indicators of UAER,SCr,BUN,HbA1c,the observation group is significantly better than the control group,the difference was statistically significant(P<0.05).From the fasting blood glucose level and the blood glucose level 2 hours after a meal,the observation group was(5.38±1.78)mmol/L and(7.42±1.59)mmol/L,respectively,which were better than the control group,the difference was statistically significant(P<0.05).From the perspective of adverse reactions,the incidence of adverse reactions in the observation group was 6.67%significantly lower than that in the control group 20.00%,but the difference between the two groups was not statistically significant(�

关 键 词：甘露饮 早期糖尿病肾病 消渴肾消 

分 类 号：R692[医药卫生—泌尿科学]