尿微量白蛋白、超敏C反应蛋白水平联合检测对2型糖尿病肾病的早期诊断价值  

The Value of Combined Detection of Urine Microalbumin and High-sensitivity C-reactive Protein Levels in the Early Diagnosis of Type 2 Diabetic Nephropathy

作　　者：谢美华[1] 李肇暖[1] 陈上卿 XIE Meihua;LI Zhaonuan;CHEN Shangqing(Department of Laboratory Medicine,the Second Hospital of Sanming City,Sanming,Fujian Province,366000 China)

机构地区：[1]福建省三明市第二医院检验科,福建三明366000

出　　处：《糖尿病新世界》2021年第13期48-51,共4页Diabetes New World Magazine

摘　　要：目的分析尿微量白蛋白(mALB)、超敏C反应蛋白(hs-CRP)水平联合检测对2型糖尿病肾病的早期诊断价值。方法将该院2020年3月—2021年3月共120例2型糖尿病肾病患者作为研究组,根据尿微量白蛋白的检出率,分为早期糖尿病肾病组60例和单纯2型糖尿病组60例,另选取同期60名健康体检者作为对照组。分别检测3组尿微量白蛋白以及hs-CRP水平,分析尿微量白蛋白、hs-CRP水平联合检测在2型糖尿病肾病中的早期诊断价值。结果早期糖尿病肾病组mALB、hs-CRP水平均高于单纯2型糖尿病组及对照组,差异有统计学意义(P<0.05);单纯2型糖尿病组mALB、hs-CRP水平均高于对照组,差异有统计学意义(t=6.502、13.223,P<0.05)。根据HbA1c水平判断2型糖尿病患者血糖控制情况,分为血糖控制良好组(HbA1c<7%)69例和血糖控制不良组(HbA1c>7%)51例。血糖控制良好组mALB以及hs-CRP低于血糖控制不良组,差异有统计学意义(t=41.417、25.015,P<0.05)。联合检测敏感度、特异度均高于mALB、hs-CRP单项测定,差异有统计学意义(χ^(2)=4.904、6.154、8.086、19.459,P<0.05)。结论mALB、hs-CRP水平联合检测在2型糖尿病肾病的早期诊断中具有较高的应用价值,能够有效提高糖尿病肾病的检出率,可为临床治疗提供更全面的参考。Objective To analyze the value of combined detection of urine microalbumin(mALB)and high-sensitivity C-reactive protein(hs-CRP)levels in the early diagnosis of type 2 diabetic nephropathy.Methods A total of 120 patients with type 2 diabetic nephropathy in the hospital from March 2020 to March 2021 were taken as the research group.According to the detection rate of urine microalbumin,they were divided into 60 patients with early diabetic nephropathy and simple type 2 diabetes group;another 60 cases of healthy physical examination during the same period were selected as the control group.The levels of urinary microalbumin and hs-CRP were detected in the three groups respectively,and the value of combined detection of urinary microalbumin and hs-CRP levels in the early diagnosis of type 2 diabetic nephropathy was analyzed.Results The levels of mALB and hs-CRP in the early diabetic nephropathy group were higher than those in the simple type 2 diabetes group and the control group,the difference was statistically significant(P<0.05);mALB and hs-CRP levels in the simple type 2 diabetes group were higher than those of the control group,and the difference was statistically significant(t=6.502,13.223,P<0.05).According to the level of HbA1c to judge the blood glucose control of type 2 diabetes patients,they were divided into a good blood glucose control group(HbA1c<7%)69 cases and a poor blood glucose control group(HbA1c>7%)51 cases.The mALB and hs-CRP in the well-controlled blood glucose group were lower than those in the poorly controlled blood glucose group,and the difference was statistically significant(t=41.417,25.015,P<0.05).The sensitivity and specificity of the combined detection were higher than the single measurement mALB and hs-CRP,the difference was statistically significant(χ^(2)=4.904,6.154,8.086,19.459,P<0.05).Conclusion The combined detection of mALB and hs-CRP levels has high application value in the early diagnosis of type 2 diabetic nephropathy,can effectively improve the detection rate of diabetic neph

关 键 词：尿微量白蛋白 超敏C反应蛋白 联合检测 2型糖尿病肾病 诊断价值 

分 类 号：R59[医药卫生—内科学]