益肾安胶囊活血化瘀作用研究  

Study on activating blood circulation and removing blood stasis of Yishen′an capsule

作　　者：赵云丽[1,3] 张若松 罗晓东 郭枫[4] 张翔华[4] 尚建华 ZHAO Yun-li;ZHANG Ruo-song;LUO Xiao-dong;GUO Feng;ZHANG Xiang-hua;SHANG Jian-hua(State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences Kunming 650201,China;University of Chinese Academy of Sciences Beijing 100049,China;Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan Provincial Center for Research&Development of Natural Products,School of Chemical Science and Technology,Yunnan University Kunming 650091,China;Kunming Institute of Kidney Disease,Kunming 650031,China)

机构地区：[1]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201 [2]中国科学院大学,北京100049 [3]云南大学教育部自然资源药物化学重点实验室云南省天然产物转化与应用重点实验室,云南昆明650091 [4]昆明肾脏病研究所,云南昆明650031

出　　处：《云南民族大学学报（自然科学版）》2021年第5期449-453,共5页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：云南省科技厅应用基础研究面上项目(2019FB116).

摘　　要：研究益肾安胶囊的活血化瘀作用,为临床应用提供实验依据.试验采用大鼠寒凝血瘀症模型,观察对血液粘度、血浆粘度、血小板活性及凝血功能的影响;采用小鼠微循环障碍模型,观察对微动脉、微静脉及毛细血管网开放数的影响.结果显示,益肾安胶囊以0.5、1.0、2.0 g/kg的剂量连续灌胃给药10 d,中、低剂量组能明显降低寒凝血瘀症大鼠的全血粘度,高剂量组可明显抑制由ADP诱导的血小板聚集;以0.35、0.7、1.4、2.8 g/kg的剂量连续灌胃给药3 d,均能明显对抗肾上腺素致微循环障碍模型小鼠的微动脉和微静脉血管收缩,对毛细血管开放数有增加趋势.提示,益肾安胶囊可降低血液粘度、抑制血小板集聚、改善微循环,为活血化瘀的功能提供了实验依据.The effect of activating blood circulation and removing blood stasis of Yishen an(YSA)capsule was studied to provide experimental basis for clinical application.The effects of blood viscosity,plasma viscosity,platelet activity and coagulation function were observed in rat model of cold coagulation and blood stasis.The effect of microcirculation disturbance on the number of arterioles,venule and capillary network was determined in mice.Results showed that,the whole blood viscosity of rats with cold coagulation and blood stasis was significantly reduced after the YSA administration for successive 10 days at 0.5 and 1.0 g/kg,and the platelet aggregation induced by ADP was significantly inhibited in the 2.0 g/k g group.In addition,YSA at 0.35,0.7,1.4,2.8 g/kg for successive 3 days significantly antagonized the arteriole and vena vena vasoconstriction in the model mice with microcirculation disturbance induced by adrenaline,and had an increasing trend in the number of capillaries open.YSA can reduce blood viscosity,inhibit platelet aggregation and improve microcirculation,which provides experimental basis for further study.

关 键 词：益肾安胶囊 活血化瘀 寒凝血瘀症 微循环障碍 

分 类 号：R285[医药卫生—中药学]