经胆道镜取石术联合消炎利胆片对老年胆石症患者的治疗作用  

Therapeutic Effects of Choledochoscopy Combined with Xiaoyanlidan Tablets on Hepatolithiasis in Elderly Patients

作　　者：叶大钊 YE Da-Zhao(Department of General Surgery,Taixing Hospital ofZaoyang City,Xiangyang 441299,China)

机构地区：[1]枣阳市泰兴医院普外科,湖北襄阳441299

出　　处：《中国药物经济学》2021年第8期92-95,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨经胆道镜取石术联合消炎利胆片对老年胆石症患者的治疗作用。方法选取2018年3月至2020年3月枣阳市泰兴医院收治的102例老年胆石症患者作为研究对象,随机分为对照组与观察组,每组51例。对照组给予经胆道镜取石术治疗,观察组采取消炎利胆片联合经胆道镜取石术治疗。比较两组患者临床疗效、肝胆功能指标、炎症介质水平、不良反应发生率。结果观察组治疗有效率为90.20%(46/51),高于对照组患者的72.55%(37/51)(P<0.05)。治疗后观察组总胆红素(TBil)、层粘连蛋白(LN)、透明质酸(HA)低于对照组(P<0.05)。治疗后观察组肿瘤坏死因子-α(TNF-α)、干扰素诱导蛋白-10(IP-10)、白细胞介素-17(IL-17)低于对照组(P<0.05)。观察组、对照组不良反应发生率分别为15.69%(8/51)、9.80%(5/51),差异无统计学意义(P>0.05)。结论消炎利胆片联合经胆道镜取石术治疗老年胆石症患者临床疗效显著,能有效改善患者的肝胆功能,减轻炎症反应,治疗安全性良好。Objective To study the therapeutic effects of choledochoscopy combined with Xiaoyanlidan Tablets on elderly patients with hepatolithiasis. Methods A total of 102 elderly patients with hepatolithiasis admitted to Taixing Hospital from March 2018 to March 2020 were selected as the research objects, and were randomly divided into a control group and an observation group with 51 cases in each group. The control group was treated with choledochoscopy, while the observation group was treated with Xiaoyan Lidan tablets combined with choledochoscopy. The clinical efficacy, liver and gallbladder function indexes, levels of inflammatory factors and incidence of adverse reactions were statistically compared between the 2 groups. Results The total effective rate of the observation group was 90.21%(46/51), which was higher than that of the control group 72.55%(37/51)(P<0.05). After treatment, the total bilirubin(TBIL), laminin(LN) and hyaluronic acid(HA) in the observation group were lower than those in the control group(P<0.05). After treatment, the levels of tumor necrosis factor-α(TNF-α), interferon induced protein-10(IP-10), interleukin-17(IL-17) in the observation group were lower than those in the control group(P<0.05). The incidence of adverse reactions in the observation group and the control group were 15.69%(8/51) and 9.80%(5/51), respectively, the difference was not statistically significant(P>0.05). Conclusion Xiaoyanlidan Tablets combined with choledochoscopy in the treatment of elderly patients with hepatolithiasis has significant clinical effect, can improve the liver and gallbladder function of patients, reduce the inflammatory reaction, and has good treatment safety.

关 键 词：胆石症 消炎利胆片 经胆道镜取石术 临床疗效 肝胆功能 炎症介质 

分 类 号：R657.4[医药卫生—外科学] R982[医药卫生—临床医学]