对乙酰氨基酚泡腾栓发泡性能的影响因素  

Influencing Factors of Foaming Property of Acetaminophen Effervescent Suppositories

作　　者：张传香[1] 何苗 马丹凤[1] Zhang Chuanxiang;He Miao;Ma Danfeng(Hunan Children’s Hospital,Hunan Changsha 410007,China)

机构地区：[1]湖南省儿童医院,湖南长沙410007

出　　处：《儿科药学杂志》2021年第9期44-47,共4页Journal of Pediatric Pharmacy

基　　金：湖南省卫生健康委员会科研计划项目,编号20200164。

摘　　要：目的:探讨对乙酰氨基酚泡腾栓发泡性能的影响因素及作用规律,为优化泡腾栓新制剂处方提供参考。方法:以最大发泡量为筛选指标,采用单因素分析考察基质与发泡剂比例、混合基质组成、吐温-80含量、柠檬酸与碳酸氢钠比例对泡腾栓成型性与发泡性能的影响。结果:以聚乙二醇(PEG)6000与发泡剂质量比为1.6∶1、吐温含量为3.9%、酸碱比为1∶2制备的对乙酰氨基酚泡腾栓发泡量最大。结论:PEG 6000为泡腾栓的良好基质,酸碱比是影响其发泡性能的主要因素。Objective:To probe into the influencing factors and laws of effect for the foaming property of acetaminophen effervescent suppositories,so as to provide reference for optimizing the prescription of new effervescent suppository preparation.Methods:The maximum foaming amount was used as the screening indicator,the effects of the mass ratio of base and foaming agent,the composition of mixed bases,the content of Tween-80 and the mass ratio of citric acid and sodium bicarbonate on the formability and foaming property were carried out via the single factor analysis.Results:The maximum foaming property of acetaminophen effervescent suppository was prepared with the mass ratio of polyethylene glycol(PEG)6000 to foaming agent of 1.6∶1,Tween content of 3.9%and acid-base ratio of 1∶2.Conclusion:PEG 6000 is the effective bases for the acetaminophen effervescent suppositories,and acid-base ratio is the main influencing factor for the foaming performance.

关 键 词：泡腾栓 发泡量 直肠给药 对乙酰氨基酚 

分 类 号：R943[医药卫生—药剂学]