One Stone Two Birds-Enantioselective Bimetallic Catalysis forα-Amino Acid Derivatives with an Allene Unit  

作　　者：Junzhe Xiao Haibo Xu Xiaohong Huo Wanbin Zhang Shengming Ma 

机构地区：[1]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,Shanghai,200032 China [2]University of Chinese Academy of Sciences,Beijing,100049 China [3]Research Centre for Molecular Recognition and Synthesis,Department of Chemistry,Fudan University,220 Handan Lu,Shanghai,200433 China [4]Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,School of Chemistry and Chemical Engineering and School of Pharmacy,Shanghai Jiao Tong University,800 Dongchuan Road,Shanghai,200240 China

出　　处：《Chinese Journal of Chemistry》2021年第7期1958-1964,共7页中国化学（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(Grant No.21690063 to S.M.,and Grant No.21901158 to X.H.)is greatly appreciated.We thank Mr.Huanan Wang in this group for reproducing the results of(R)-3'd,(Rm-3and(R)-17k,presented in Tables 2,3,and 4,respectively.

摘　　要：Main observation and conclusion A highly enantioselective 2,3-allenylation of acyclic and cyclicα-imino carboxylates via a synergistic bimetallic Pd/Cu catalysis with the same commercially available(R,Rp)-iPr-FOXAP(also as Phosferrox,(R,R)-[2-(4’-i-propyloxazolin-2’-yl)ferrocenyl]diphenyl phosphine)ligand for both metals affording optically active 2,3-butadienylα-amino acid derivatives in high to excellent yields with excellent enantioselectivities has been developed.

关 键 词：Amino acids ALLENE Synergistic bimetallic Pd/Cu catalysis Enantioselective synthesis Mechanism 

分 类 号：O62[理学—有机化学]