血必净注射液对慢性阻塞性肺疾病急性加重期患者炎症标志物及细胞免疫功能的影响  

Effect of xuebijing injection on inflammatory markers and cellular Immune function in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：裴旭东[1] 颜成果 王立坤 闪海霞[1] 卢瑞杰[1] Pei Xudong;Yan Chengguo;Wang Likun;Shan Haixia;Lu Ruijie(Department of Infectious Liver Diseases,Nanyang Central Hospital,Nanyang 473009,China)

机构地区：[1]河南省南阳市中心医院感染肝病科,473009

出　　处：《中国实用医刊》2021年第14期104-107,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨血必净注射液对慢性阻塞性肺疾病急性加重期患者炎症标志物及细胞免疫功能的影响。方法抽取2018年5月至2020年5月南阳市中心医院收治的慢性阻塞性肺病急性加重期患者76例,随机数字表法分为参照组与研究组,参照组38例给予常规抗感染、解痉、对症支持治疗,研究组38例在常规治疗基础上联合血必净注射液治疗,比较两组治疗前后肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)、血清T淋巴细胞亚群各指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))变化情况。结果治疗前,两组TNF-α、IL-6、CRP、PCT水平与CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平比较,差异未见统计学意义(P>0.05)。治疗后,两组TNF-α、IL-6、CRP、PCT水平低于治疗前,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于治疗前,CD8^(+)水平低于治疗前(P<0.05)。治疗后,研究组TNF-α、IL-6、CRP、PCT水平低于参照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于参照组,CD8^(+)水平低于参照组(P<0.05)。结论慢性阻塞性肺疾病急性加重期患者给予血必净注射液治疗,有利于降低炎症标志物水平,提高细胞免疫功能,改善机体炎症反应,提高免疫机能。Objective To investigate the effect of xuebijing injection on inflammatory markers and cellular immune function in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods A total of 76 patients with acute exacerbation of chronic obstructive pulmonary disease in Nanyang Central Hospital from May 2018 to May 2020 were selected,they were randomly divided into control group and study group according to random number method,the reference group(38 cases)was given routine anti infection,antispasmodic and symptomatic support treatment,and the study group(38 cases)was combined with xuebijing injection on the basis of routine treatment.The levels of tumor necrosis factor-α(TNF-α),the changes of interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT),serum T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))between the two groups were compared before and after treatment.Results Before treatment,the levels of TNF-α,IL-6,CRP and PCT were compared with those of CD3,CD4,CD8 and CD4/CD8 in the two groups,the difference was not statistically significant(P>0.05).After treatment,the levels of TNF-α,IL-6,CRP and PCT in the two groups were lower than before treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were higher than before treatment,and the levels of CD8^(+)were lower than before treatment(P<0.05).After treatment,the levels of TNF-α,IL-6,CRP and PCT in the study group were lower than those in the control group,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were higher than those in the control group,and the levels of CD8^(+)were lower than those in the control group(P<0.05).Conclusions The treatment of xuebijing injection in the acute exacerbation stage of chronic obstructive pulmonary disease is helpful to reduce the level of inflammatory markers,improve cellular immune function,improve the inflammatory response of the body,improve the immune function.

关 键 词：慢性阻塞性肺疾病 急性加重期 血必净注射液 炎症标志物 细胞免疫 

分 类 号：R563.9[医药卫生—呼吸系统]