晚期恶性肿瘤并发多器官功能障碍综合征患者急救预后的影响因素分析  

Analysis of Factors Affecting the Prognosis of Patients with Advanced Malignant Tumors Complicated by Multiple Organ Dysfunction Syndrome

作　　者：王晓燕[1] 孙建刚[1] WANG Xiaoyan;SUN Jiangang(Department of Oncology,Zibo Maternity and Child Health Hospital,Zibo,Shandong Province,255000 China)

机构地区：[1]淄博市妇幼保健院肿瘤科,山东淄博255000

出　　处：《世界复合医学》2021年第7期99-101,共3页World Journal of Complex Medicine

摘　　要：目的分析和研究晚期恶性肿瘤并发多器官功能障碍综合征患者急救预后的影响因素。方法研究对象为2015年10-2019年10月在该院收治的80例晚期恶性肿瘤患者,根据患者入院后1个月的预后情况将其分为生存组(36例)和死亡组(44例)。将两组患者临床资料中的性别、年龄、APACHEⅡ评分、MODS评分、C反应蛋白(CRP)、氧合指数、乳酸、血小板、白细胞计数、慢性病史进行分析。结果通过单因素分析可知生存组和死亡组性别比(22:14 vs 28:16)及慢性病史(21 vs 30)差异无统计学意义(χ^(2)=0.054、0.831,P>0.05)。生存组和死亡组APACHEⅡ评分[(31.23±3.65)分vs(37.02±4.52)分]、MODS评分[(12.83±2.41)分vs(16.13±3.61)分]、CRP[(39.73±6.51)mg/L vs(93.52±18.45)mg/L]、乳酸[(5.02±1.23)μmol/L vs(12.01±2.75)μmol/L]及血小板计数[(119.03±17.52)×109L vs(148.93±28.34)×109L]对比差异有统计学意义(t=6.205、4.693、16.649、14.126、5.522,P<0.05)。通过多因素Logistic回归分析可知,APACHEⅡ评分、MODS评分及乳酸是影响预后的独立风险因素(P<0.05)。结论晚期恶性肿瘤并发多器官功能障碍综合征患者急救预后的影响因素包括APACHEⅡ评分、MODS评分及乳酸,临床需加以重视。Objective To analyze and study the factors affecting the prognosis of patients with advanced malignant tumors complicated by multiple organ dysfunction syndrome.Methods The subjects of the study were 80 patients with advanced malignant tumors admitted to our hospital from October 2015 to October 2019.According to the prognosis of the patients one month after admission,they were divided into survival group(36 cases)and death group(44 cases).The gender,age,APACHE II score,MODS score,C-reactive protein(CRP),oxygenation index,lactate,platelet,white blood cell count,and chronic disease history in the clinical data of the two groups of patients were analyzed.Results The univariate analysis showed that the gender ratio(22:14 vs 28:16)and chronic disease history(21 vs 30)of the survival group and the death group were not statistically significant(χ^(2)=0.054,0.831,P>0.05).In survival group and death group,the differences in APACHEⅡscore of survival group and death group[(31.23±3.65)points vs(37.02±4.52)points],MODS score[(12.83±2.41)points vs(16.13±3.61)points],CRP[(39.73±6.51)mg/L vs(93.52±18.45)mg/L],lactic acid[(5.02±1.23)μmol/L vs(12.01±2.75)μmol/L]and platelet count[(119.03±17.52)×109L vs(148.93±28.34)×109L]were statistically significant(t=6.205,4.693,16.649,14.126,5.522,P<0.05).Multivariate logistic regression analysis showed that APACHEⅡscore,MODS score and lactate were independent risk factors affecting the prognosis(P<0.05).Conclusion The factors affecting the prognosis of patients with advanced malignant tumors complicated by multiple organ dysfunction syndrome include APACHE II score,MODS score and lactic acid,which should be paid attention to in clinical practice.

关 键 词：晚期恶性肿瘤 多器官功能障碍综合征 急救预后 影响因素 

分 类 号：R4[医药卫生—临床医学]