美托洛尔联合阿司匹林治疗急性心肌梗死患者的临床疗效研究  

Study on the Clinical Efficacy of Metoprolol Combined with Aspirin in the Treatment of Patients with Acute Myocardial Infarction

作　　者：赵丽红 ZHAO Lihong(Emergency Department,Mudan People's Hospital of Heze City,Heze,Shandong Province,274000 China)

机构地区：[1]菏泽市牡丹人民医院急诊科,山东菏泽274000

出　　处：《世界复合医学》2021年第7期143-145,共3页World Journal of Complex Medicine

摘　　要：目的分析美托洛尔联合阿司匹林治疗急性心肌梗死患者的临床治疗效果。方法在2018年4月-2019年12月间该院收治患者中抽选出自愿参加研究的急性心肌梗死患者96例作为研究对象,先入院接受治疗的48例患者纳入对照组,单纯接受阿司匹林治疗,后入院进行治疗的48例患者纳入观察组,接受美托洛尔+阿司匹林治疗,检测两组患者超声心动图参数与血浆B型脑钠肽(BNP)水平,比较应用效果。结果观察组患者的左心室射血分数(LVEF)水平(47.60±4.67)%明显较对照组(40.83±5.06)%更高,且左心室舒张末期容积指数(LVEDVI)水平(67.42±7.89)mL/m^(2)、BNP水平(114.86±19.37)ng/mL均显著较对照组(73.11±8.45)mL/m^(2)、(156.77±21.20)ng/mL低,差异有统计学意义(t=6.812、3.410、10.111,P<0.05);观察组临床有效率是79.17%(38/48),较对照组数据50.00%(24/48)更高,差异有统计学意义(χ^(2)=8.926,P<0.05)。结论对于急性心肌梗死患者,临床给予美托洛尔与阿司匹林联合治疗的有效性较高,有助于积极改善患者的心功能指标,减少心血管事件发生风险。Objective To analyze the clinical therapeutic effect of metoprolol combined with aspirin in the treatment of patients with acute myocardial infarction.Methods From April 2018 to December 2019,96 patients with acute myocardial infarction who voluntarily participated in the study were selected as the research subjects.The 48 patients who were first admitted to the hospital for treatment were included in the control group and received only aspirin.After treatment,48 patients who were admitted to the hospital for treatment were included in the observation group and received metoprolol+aspirin treatment.The echocardiographic parameters and plasma B-type brain natriuretic peptide(BNP)levels of the two groups were tested to compare the application effects.Results The left ventricular ejection fraction(LVEF)level(47.60±4.67)%of the observation group was significantly higher than the control group(40.83±5.06)%,and the left ventricular end diastolic volume index(LVEDVI)level(67.42±7.89)mL/m^(2) and the BNP level(114.86±19.37)ng/mL were both significantly lower than the control group(73.11±8.45)mL/m^(2),(156.77±21.20)ng/mL,the difference was statistically significant(t=6.812,3.410,10.111,P<0.05);the clinical effective rate of the observation group was 79.17%(38/48),which was higher than the control group data 50.00%(24/48),the difference was statistically significant(χ^(2)=8.926,P<0.05).Conclusion For patients with acute myocardial infarction,the clinical administration of metoprolol and aspirin is more effective,which helps to actively improve the patient's cardiac function indicators and reduce the risk of cardiovascular events.

关 键 词：美托洛尔 阿司匹林 急性心肌梗死 左心室射血分数 血浆B型脑钠肽 

分 类 号：R4[医药卫生—临床医学]